摘要
目的探讨β-catenin、Smad4在胰腺癌发生、发展、转移、浸润过程中的作用。方法应用免疫组化方法检测β-catenin、Smad4在正常胰腺、胰腺癌组织中的表达。结果β-catenin在胰腺癌中的异常表达率为68.33%,明显高于正常组织(0),异常表达与年龄、性别、病理分化程度无关;与有无淋巴结转移、临床分期相关,有淋巴结转移的异常表达率明显高于无淋巴结转移,Ⅲ+Ⅳ期的异常表达率明显高于Ⅰ+Ⅱ期。Smad4在胰腺癌的阳性表达(33/60)明显低于正常组织(17/20),阳性表达与年龄、性别、病理分化程度、有无淋巴结转移、临床分期无相关性;在胰腺癌中β-catenin的异常表达与Smad4的阳性表达相关。结论β-catenin、Smad4共同参与了胰腺癌的发生,wnt/β-catenin通路和TGF-β/Smad通路可能存在交汇点。
Objective To investigate the abnormal expression of β- catenin and Smad4 in pancreatic carcinomas and its relationship with the biological behavior. Methods Immunohistochemistry was used to detect β - catenin and Smad4 in pancreatic carcinomas and normal pancreatic tissues. Results The abnormal rate olin- catenin expression in pancreatic carcinomas was 68.33% （41/ 60） ,higher than the rate of normal pancreatic tissues＂ expression （0.0%）. The significant relationship was observed between β- catenin ex- pression and clinical stages and lymph node spread （P〈0; 05）. Compared with the normal pancreatic tis- sues, the overexpression of Smad4 in pancreatic carcinomas was 55% （33/60）. There was a significant difference（P〈0.05）. No significant difference was found between the abnormal expression of β- catenin and Smad4 and the patients age, sex, tumor size and differentiation （P〉0.05）. There was a significant re- lationship between the abnormal expression of β- catenin and Smad4. Conclusions β- catenin,Smad4 par- ticipate the tumorigenes of pancreatic cancer. There was signaling cross- talk between wnt/β- catenin and TGF - β/Smad pathways.
出处
《中国煤炭工业医学杂志》
2012年第6期791-793,共3页
Chinese Journal of Coal Industry Medicine
