摘要
采用限制性片段长度多态性（ＲＦＬＰ）方法对北京（６０例）和湖北（５８例）地区随机人群的补体Ｃ４基因的长度进行检测。结果：湖北人群Ｃ４短基因的分布频率较北京人群高，其表型频率分别为 ７９． ３１％、６１．４４％，基因频率分别为５１．７２％、３７．５０％，差异均有显著意义（均为Ｐ＜０．０５），而且Ｃ４短基因在上述二个人群中的分布均符合Ｈａｒｄｇ－Ｗｅｎｂｅｒｇ平衡。结果表明，湖北人群Ｃ４短基因的频率高于北京人群。这种由于逆转录病毒序列的插入所致的Ｃ４基因长度的变化为研究某些疾病的遗传易感性提供了线索。
To study the difference in the distribution of C4 short gene between Hubei and Beijing population, the samples from Hubei and Beijing population were tested for the RFLP typing of C4 gene. The results showed that the phenotype frequencies of C4 short gene were 79. 31 % (Hubei ) and 61. 44% (Beijing), the gene frequencies of the C4 short gene 51. 72% (Hubei) and 37. 50% (Beijing) respectively with the differences being significant (P<0. 05). It was concluded that the C4 short gene is more frequent in Southern Chinese than that in Northern Chinese. As the length difference of C4 gene is due to the insertion of a retrovirus sequence, the finding supplies a clue to study the susceptibity to some diseases.
出处
《同济医科大学学报》
CSCD
2000年第1期8-10,共3页
Acta Universitatis Medicinae Tongji
基金
国家自然科学基金!(No.39200065)
湖北省自然科学基金!(NO.98J107)
