摘要
目的了解住院患者抗菌药物临床使用情况及存在的问题。方法对我院2010年随机抽取的住院手术病例400例及非手术病例400例抗菌药物的用药频度(DDDs)和费用情况进行调查分析。结果我院2010年DDDs排序前三位的抗菌药物为左氧氟沙星、哌拉西林钠-舒巴坦钠和奥硝唑注射液;预防用药>72 h的病例占84.00%。非手术的400例中使用抗菌药物者128例(32.00%):治疗性用药92例(71.88%),预防性用药36例(28.12%);单用一种抗菌药物94例(73.44%),二联用药34例(26.56%),无三联及以上用药。手术的400例中324例(81.00%)为预防性用药;术前使用抗菌药物12例(3.00%)、术后24 h内停用6例(1.50%),术后>24～48 h用药13例(3.25%),>48～72 h用药45例(11.25%),>72 h用药336例(84.00%)。400例手术患者中Ⅰ类切口无联合用药情况,Ⅱ类切口联合用药113例(42.64%)。结论住院患者抗菌药物使用情况存在细菌培养送检率较低、手术患者预防用药时间长、抗菌药物选择不当等问题,应加强与规范临床合理用药。
Objective To determine the application features and problems of antibacterials for inpatients in our hospital. Methods The antibacterials used by 400 inpatients and 400 nonoperative patients in our hospital during 2010 were retrospectively analyzed according to their consumption, DDDs and cost. Results The top 3 antibacterial drugs of DDDs were Levo- floxacin, Piperacillin sodium and Sulbactam sodium, Ornidazole; The rate of surgical patients in the time of antibiotics utilization over 72 h was 84%. Among 400 non-operative patients, 128 （32.00%） had antibacterials, including 92 （71.88%） with remedial medication and 36 （28.12%） with prophylactic medication; 94 （73.44%） had single drug, 34 （26. 56% ） had duple treatments. Among 400 operated patients, 324 （81.00%） had remedial medication, 12 （3.00%） had antibacterials before surgery, 6 （ 1.50% ） withdrew 24 h after surgery, 13 （3.25%） were administered during 24-48 h, 45 （ 11.25% ） during 48-72 h, and 336 （84.00%） were administered at 72 h. 113 operated patients with grade II incision received drug combination. Conclusion Unreasonable factors exist in the use of antibiotics during perioperative period, such as low rate of specimen examination, the prolonged drug use and inappropriate antibacterials selection. It＇s necessary and urgent to surpervise the management of application of antibacterials.
出处
《临床误诊误治》
2012年第6期75-77,共3页
Clinical Misdiagnosis & Mistherapy
基金
武警部队重点项目(WJHQ2010-16)
关键词
抗菌药
合理用药
调查分析
Anti-bacterial agent
Rational use of drug
Investigation analysis
