摘要
目的研究巴中地区近3年育龄人群感染弓形体、其他微生物、风疹病毒、巨细胞病毒、单纯疱疹病毒(TORCH)的情况,探讨不良妊娠与TORCH感染的关系以及不同季节TORCH感染的流行情况。方法采用酶联免疫吸附试验(ELISA)抽样检测巴中地区近3年2 159例TORCH的抗体水平,比较孕前育龄男性组、育龄女性组、健康妊娠组和不良妊娠组、婴幼儿组特异性抗体阳性率,城市和农村人群TORCH抗体的阳性率,不同季节感染阳性率。结果 2009～2011年TORCH分析孕前育龄男性组、育龄女性组及婴幼儿组TORCH抗体阳性率分别为7.4%、14.7%和12.9%,3组间差异无统计学意义(χ2=2.22,P>0.05);3组间巨细胞病毒抗体(CMV-IgM)阳性率比较,婴幼儿组抗体阳性率为11.2%,较其他两组明显升高,差异有统计学意义(χ2=20.3,P<0.05)。与动物有接触史者弓形虫抗体(TOX-IgM)阳性率为8.2%,无接触史者TOX-IgM阳性率为1.9%,差异有统计学意义(χ2=57.1,P<0.05)。不良妊娠组妇女所有TORCH项目的IgM阳性率均显著高于健康妊娠组妇女,差异有统计学意义(χ2=31.6,P<0.05);城市人群TOX-IgM阳性率为6.9%,农村为17.4%,差异有统计学意义(χ2=31.3,P<0.05)。春、夏季TORCH-IgM总阳性率和TOX、CMV、单纯疱疹(HSV)的IgM阳性率明显高于秋、冬季,差异均有统计学意义(χ2=28.6,P<0.05),而风疹病毒(RUV-IgM)阳性率冬、春季显著高于夏、秋季,差异均有统计学意义(χ2=24.6,P<0.05)。结论 TORCH感染无性别、年龄差异,普遍易感。农村人群与家畜接触机会多,感染机会大。因季节不同,机体抵抗力有差异,感染率需要实际关注,尤其是孕妇、儿童免疫力下降极易被感染。因此建议将TORCH检测作为育龄夫妇常规检测项目。
Objective To investigate the situation of toxoplasma, rubella, cytomegalovirus,herpes （TORCH） infections in Bazhong area in the past three years and to explore the relationship between adverse pregnancy with TORCH infection and the prevalent status of TORCH infections during different seasons. Methods The antiboby levels of TORCH were detected using enzyme--linked immunosorbent assay（ELiSA） in 2 159 individuals in Bazhong area by sampling method. The positive rates of TORCH antibody and infections were compared among prepregnancy childbearing age men, childbearing age women, healthy pregnancy, adverse pregnancy and infants, between urban and rural populations and among different seasons. Results The positive rate of TORCH antibody was 7. 4% in the prepregnancy childbearing age men group, 14.7% in the childbearing age women group and 12.9~ in the infants group, respectively, without statistical diffefence among three groups （x2 = 2.22, P〉0.05 ）. The positive rate of cyto- megalovirus （CMV） IgM was 11.2 % in the infant group,which significantly higher than that in the other two groups with statistical difference between them（x2 = 20.3, P〈0.05）. The positive rate of toxoplasma （TOX） lgM was 8. 2 %in the individuals with the history of contacting animals and 1.9 % in the individuals without the history of con- tacting animals,showing statistical difference between them （x2= 57.1, P〈0.05）. The positive rate of IgM in all TORCH items in the adverse pregnancy group was significantly higher than that in the healthy pregnancy group with statistical difference （x2 =31.6,P〈0.05）. The positive rate of TOX-IgM was 6.9% in the urban populations and 17.4 % in the rural populations with statistical difference（x2= 31.3, P〈0.05）. The total positive rate of TORCH IgM and the positive rate of TOX,CMV, HSV IgM in spring and summer were higher than those in autumn and win ter with statistical difference（x2 =28.6 ,P〈0.05）. The positive rate of RUV-IgM in spring and winter was higher than that in summer and autumn with statistical difference（x2 =24：6 ,P〈0.05）. Conclusion TORCH infections are generally susceptible in both genders and among all age groups. Then rural populations have higher risk due to high opportunity to contact with animals. The body resistance is different due to different seasons. The infection rate should need to be practically concerned. Especially,pregnant women and children are easily infected by TORCH due to weakened immunity. Therefore, it is suggested that the TORCH test should be routinely performed among couples of reproductive age.
出处
《检验医学与临床》
CAS
2012年第12期1449-1450,1452,共3页
Laboratory Medicine and Clinic
