摘要
目的:观察小檗碱对糖尿病肾病大鼠C反应蛋白的影响。方法:将48只雄性SD大鼠随机分为空白对照组、模型组、小檗碱75、150及300mg.kg-1组、罗格列酮组六组,每组8只。除正常对照组外,其余各组大鼠腹腔注射链脲佐菌素(STZ,55mg.kg-1),成功造模后小檗碱各组及罗格列酮组分别灌胃给予75、150、300mg.kg-1小檗碱以及4mg.kg-1罗格列酮,连续6w后检测大鼠血糖、体重,HE染色检测肾脏病理改变,ELISA法检测C反应蛋白活性。结果:与正常对照组相比,糖尿病组血糖与C反应蛋白活性明显升高(P<0.05),与模型组比较,小檗碱各组血糖与C反应蛋白活性明显降低(P<0.05),有统计学意义。结论:小檗碱可降低糖尿病大鼠血糖和C反应蛋白,减轻糖尿病肾病。
Objective.. To study the effects of berberine on C-reactive protein expression in diabetic nephropathy rats. Methods： 48 male SD rats were divided into model group, control group, rosiglitazone group, berberine 75,150,300 mg·kg^-1 groups randomly, n=8. Diabetes was induced by intraperitoneal injection with 55 mg·kg^-1 streptozotocin （STZ）. 4 mg·kg^-1 rosiglitazone and 75, 150,300mg·kg^-1 berberine were administrated orally for 6 weeks. The blood glucose, body weight were measured 6 weeks later. Pathological changes in the kidney were measured by hematoxylin and eosin stain, content of C-reactive protein was detected by ELISA. Results： Compared with normal group, C-reactive protein and blood glucose level were increased obviously in model group （P〈0.05） ; compared with model group, C-reactive protein and blood glucose level were decreased obviously in berberine groups （P〈0.05）. Conclusion： Berberine could decrease the blood sugar level, and this effect is relatived with decreasing the expression of C-reactive protein.
出处
《四川生理科学杂志》
2012年第2期51-53,共3页
Sichuan Journal of Physiological Sciences
基金
四川省卫生厅资助课题(编号:100590)
关键词
小檗碱
罗格列酮
C反应蛋白
糖尿病肾病
Berberine
Rosiglitazone
C-reactive protein
Diabetic nephropathy
