摘要
药物性肝损伤(DILI)是指由药物本身或其代谢产物引起的肝损害,目前逐渐被认为是发生急、慢性肝病的一个重要原因。有报道显示DILI发病率在1/10 000～1/100 000之间,但随着新药的不断研发和临床应用,其发病率有逐年上升趋势。为更有效地诊断和监测日益增多的DILI,本文将集中于DILI危险因素、临床表现、诊断与因果关系评价、早期临床检测及防治策略等重要临床方面的最新研究进展作一简要综述。
Drug-induced liver injury（DILI） occurs when drugs or their metabolites cause damage to hepatic tissues.In recent years,DILI has been recognized as a significant cause of both acute and chronic liver disease.The current estimates of DILI incidence worldwide range from 1 in 10,000 to 1 in 100,000,and the reported annual incidence rates have increased in parallel with increases in development of new drugs and more widespread clinical applications.There is an urgent clinical need to more effectively recognize at-risk patients and diagnose DILI in a timely manner.In this article,we will review the latest research findings concerning several important clinical aspects of DILI,including risk factors,clinical presentation,diagnosis,causality assessment,early clinical detection,and prevention strategies.
出处
《临床肝胆病杂志》
CAS
2012年第6期477-481,共5页
Journal of Clinical Hepatology
关键词
肝炎
中毒性
hepatitis
toxic
