摘要
目的比较艾司西酞普兰和度洛西汀治疗抑郁症的疗效和安全性。方法采用病例对照研究的方法,将88例符合CCMD-3的抑郁症患者随机分为两组,分别给予艾司西酞普兰(10mg/日)或度洛西汀(60mg/日)口服治疗,疗程6周,治疗前后采用汉密尔顿17项抑郁量表(HAMD-17)评定临床疗效,采用抗抑郁药副反应评定量表(SERS)评定不良反应。结果①两组治疗后HAMD-17分值(分别为5.97±3.17,6.01±3.28)较治疗前(分别为23.81±3.06,24.05±2.87)明显下降,均有统计学意义(P<0.05);②治疗第1、2、4、6周末,两组间HAMD-17减分率无显著性差异(P>0.05);③在第一周末,两组减分率无显著性差异,但与治疗前比均有显著性变化;④艾司西酞普兰组不良反应发生率小于度洛西汀组。结论艾司西酞普兰和度洛西汀均能有效治疗抑郁症,两者疗效相当,起效快速,二者不良反应轻微,但艾司西酞普兰不良反应发生率较度洛西汀少。
Objective To explore clinical efficacy and safety of escitalopram and duloxetine in treatment of depression.Methods A case-control study was made 88 patients who met CCMD-3 criteria of depression were included and administered with escitalopram or duloxetine for 6 weeks,and evaluated with Hamilton Depressive Scale（HAMD-17）and Side Effects Rating Scale（SERS）before treatment and 2,4,6 weeks after treatment.Results ①The scores of HAMD-17 after treatment（5.97±3.17,6.01±3.28 respectively）were significantly lower than before treatment（23.81±3.06,24.05±2.87 respectively）in patients treated escitalopram or duloxetine（P〈0.05）;②The reduced rates at the 1,2,4,6 weeks were all no significant difference between in patiets treated by escitalopram and by duloxetine（P〉0.05）;③At the end of the first week,there was no significant difference in reduced rates between two groups,but there was significant changes when compared with before treatment;④There was less adverse reactions in escitalopram group than in duloxetine group.Conclusion Escitalopram and duloxetine are effective and safe in treatment of depression,and their efficacy are similar.Their adverse reacitions are mild,but escitalopram less than duloxetine.
出处
《中国健康心理学杂志》
2012年第6期801-803,共3页
China Journal of Health Psychology
