摘要
应用黄芩甙150mg/kg.d及甘草流浸膏7.5ml/kg.d分别灌胃治疗病程两周的糖尿病大鼠模型1周,发现治疗前后糖尿病鼠的血糖水平无明显下降,但红细胞山梨醇含量于治疗后显著降低,提示两药在动物体内也有醛糖还原酶抑制作用,有可能用于糖尿病慢性并发症的防治。
10 streptozotocin-induced diabetic rats were treated with baicalin 150mg/kg·d and liquid extract of licorlce(LEL) 7.5ml/kg·d (5 by each medicine) for a week. The results indicated that orally baicaliu and LEL could dramatically reduce the sorbitol levels in red blood cells(123.7±28.6 to 72.5±21.8 and 116.9±25.2 to 80.5±23.8nmol/g·Hb, respectively) without affecting blood glucose levels significantly. It is suggested that both medicines act by inhibiting aldose reductase.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1990年第7期49-51,共3页
China Journal of Chinese Materia Medica
关键词
糖尿病
黄苓甙
山梨醇
diabetes mellitus
sorbiool pathway
aldose reductase inhibitor
Chinese materia medica
