摘要
目的研究自发性脑出血(ICH)患者应激性高血糖的发生及其对死亡率的影响,探讨ICH高血糖与炎症的关系。方法以2011年3月至12月入住汕头大学医学院第二附属医院的48例ICH患者为研究对象。根据格拉斯哥昏迷测量表(GCS)评分将患者分为轻中度组及重度组。检测患者入院当天及入院后第3天血糖水平。检测入院时血C反应蛋白(CRP)水平,记录入院当天白细胞计数及血压。结果重度ICH血糖及CRP水平显著高于轻中度患者(P<0.05);入院当天血糖水平与白细胞计数呈正相关;死亡病例比存活病例具有较高的血糖水平。结论 ICH患者发生应激性高血糖,血糖高低与病情轻重有关,且可预测30d内死亡率,这可能与其参与局部及全身性炎症有关。
Objective To investigate the occurrence of stress hyperglycemia and its effect on patients mortality, and to explore its correlation with inflammation. Methods Forty-eight patients with ICH, who were ad- mitted to Second Affiliated Hospital, Shantou University Medical College, from March to December 2011 were en- rolled in this study. Plasma was collected at admission and the day after admission. Glassgow Coma Scale were used to determine the patient conditions. Blood glucose and CRP were determined. Leucocytes （WBC） counts and blood pressure were recorded. Results Plasma glucose and CRP concentration were significantly increased in se- vere ICH patients than those of mild and moderate（P〈0.05）. There was a significant association between higher glucose concentration and higher WBC counts. The higher glucose concentration predicts 30 d mortality. Conclu- sion ICH patients had stress hyperglycemia, which could predict 30 days mortality. It may contribute to local or systemic inflammation.
基金
国家自然科学基金(81172088)
关键词
脑出血
高血糖症
死亡率
Cerebral hemorrhage
Hyperglycemia
Mortality
