摘要
目的探讨早期康复联合帕罗西汀对卒中后抑郁患者神经功能缺损及日常生活能力的影响。方法将126例卒中后抑郁患者随机分为对照组与观察组,给予60例对照组患者早期康复治疗,66例观察组患者在早期康复基础上接受帕罗西汀口服治疗。采用汉密尔顿抑郁量表(HAMD)、美国国立卫生研究院卒中量表(NIHSS)、改良Barthel指数及脑卒中影响量表(SIS 310)评估患者抑郁状态、神经功能缺损程度、日常生活能力及生活质量。结果治疗3个月后观察组HAMD评分、NIHSS评分、改良Barthel及SIS310评分均显著优于对照组,差异有统计学意义(P<0.05)。结论早期康复联合帕罗西汀治疗卒中后抑郁患者,可显著改善患者神经功能缺损及日常生活能力,提高生活质量。
Objective To explore the influence of rehabilitation combined with Paroxetine on neurological deficit and abili- ty of daily life in post-stroke depression. Methods 126 cases with post-stroke depression were randomly divided into control group and experience group. 60 cases of control group were given early rehabilitation, and 66 patients of experience group received Paroxetine treatment based on early rehabilitation. HAMD, NIHSS, modified barthel index and SIS 310 were used to evaluate depression state, the neurological deficit, ability of daily life and life quality. Results HAMD, NIHSS, modified barthel index and SIS 310 in experience group were much better than that in controls with significant difference （P 〈 0.05）. Conclusion Early rehabilitation compared Paroxetine for post-stroke depression can improve the neu- rological deficit, ability of daily life and life quality.
出处
《中国医药导报》
CAS
2012年第16期171-172,共2页
China Medical Herald
