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可卡因-苯丙胺转录调节肽与糖尿病关系研究进展

Research progress about cocaine and amphetamine regulated transcript in diabetes
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摘要 可卡因-苯丙胺转录调节肽(cocaine and amphetamineregulated transcript,CART)是一种丰富表达下丘脑及胰腺组织的神经肽。该文就CART基因表达与糖尿病易感性、CART对进食和胰岛素分泌的调节及其自身表达调控、CART受体及可能的受体后信号通路进行阐述,并提出CART与糖尿病关系,研究亟待解决的问题。 Cocaine and amphetamine regulated transcript（CART） is a recently described neuropeptide widely expressed in the hypothalamus and pancreas.This review describes the relationship between CART gene expression and the susceptibility to diabetes,the evidences of CART in food intake and insulin secretion,and CART expression modulation.Finally,CART receptors and potential post-receptor signaling pathways are also described,problems to be solved are put forward as well.
作者 隆敏 周世文
机构地区 第三军医大学附属新桥医院内分泌科 第三军医大学附属新桥医院国家药品临床研究基地
出处 《中国药理学通报》 CAS CSCD 北大核心 2012年第7期908-910,共3页 Chinese Pharmacological Bulletin
基金 重庆市自然科学基金资助项目(No 2009BA5012)
关键词 可卡因-苯丙胺转录调节肽(CART) 糖尿病 下丘脑 胰腺 神经肽Y 瘦素 CART； diabetes； hypothalamus； pancreas； NPY； leptin
分类号 R5 [医药卫生—内科学] R341.6 [医药卫生—基础医学]
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参考文献11

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  • 3Prokunina-Olsson L, Hall J L. Evidence for neuroendocrine func- tion of a unique splicing form of TCF7L2 in human brain, islets and gut[ J]. Diabetologia,2010,53(4) :712 - 6.
  • 4Lakatos A, Prinster S, Vicentic A, et al. Cocaine- and ampheta- mine-regulated transcript (CART) peptide activates the extracellu- lar sigual-regulated kinase (ERK) pathway in AtT20 cells via pu- tative G-protein coupled receptors [ J ]. Neurosci Lett, 2005,384 : 198 - 202.
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二级参考文献25

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中国药理学通报
2012年 第7期

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