摘要
目的对pH依赖型肠康宁结肠靶向胶囊体外释放性能进行评价,探讨制备中药结肠靶向制剂的可行性。方法以木犀草素为评价指标,采用体外释放度测定法对该制剂的体外释放性能进行评价。结果体外释放度试验结果表明,木犀草素在人工胃液2h后未见释放,在人工小肠液4h后未见释放,在人工结肠液1h后有一定的释放,2h后释放较高。结论该制剂能在结肠定位释药。
Objective To evaluate the in vitro release property and assess the feasibility for preparation of pH-dependent Changkangning Colon-Targeting Capsule. Methods Luteolin was used as the evaluation index to determine the in vitro release of the capsule. Results The in vitro release testing results showed that luteolin was released neither in artificial gastric juice after two hours, nor artificial＇intestinal fluid after four hours. While after one hour in artificial colonic, luteolin was partially released which was higher after two hours. Conclusion The capsule can fulfill the aim of targeting release in colon.
出处
《中国药事》
CAS
2012年第5期453-455,共3页
Chinese Pharmaceutical Affairs
基金
甘肃省科技支撑计划项目(编号0804NKCA119-08)
兰州市科技计划项目(编号2008-1-172)
关键词
肠康宁胶囊
结肠靶向
体外释放评价
木犀草素
Changkangning Capsule
colon-targeting
releasing evaluation in vitro
luteolin
