摘要
肝纤维化是由于基质金属蛋白酶(matrix metalloproteinases,MMPs)及其组织抑制因子(tissue inhibitor of metalloproteinasas,TIMPs)比例失调,造成细胞外基质大量沉积在细胞间质中,引起的病理改变。目前研究发现MMP-9在肝纤维化形成过程中有诱发和促进作用,但也有一些相反的意见,认为其具有逆转肝纤维化的作用,与肝纤维化呈负相关。因此,本文就近年来对MMP-9功能的研究作一概述。
Liver fibrosis is caused by the imbalance between matrix metalloproteinases （MMPs） and tissue inhibitor of metalloproteinasas （TIMPs） , which can result in the deposition of a large number of extraeellular matrix in the interstitial cells and the pathological changes. The current studies have found that MMP-9 plays an important role in the process of inducing and promoting liver fibrosis. On the contrary, there are some opinions that MMP-9 can reverse liver fibrosis and there is a negative correlation between MMP-9 and liver fibrosis. Therefore, this review will elucidate the new advances on the function of MMP-9 in recent years.
出处
《胃肠病学和肝病学杂志》
CAS
2012年第6期586-588,共3页
Chinese Journal of Gastroenterology and Hepatology
基金
国家自然科学基金项目(81170389)
陕西省自然科学基础研究计划项目(2010K15-03-06)
