摘要
本文报道用高效液相色谱法研究健康受试者口服萘普生钠片剂与胶囊剂的生物利用度及药物动力学。HPLC 分析采用C_(18)反相色谱柱,UV 检测器,检测波长262nm。流动相为甲醇:醋酸—醋酸钠缓冲液(pH3.5)=70:30,内标为消炎痛。8例健康志愿音交叉服用片剂和胶囊剂550mg 后,测定34h 内不同时相的血浓度结果表明,两种剂型除了Tmax 有显著差异外(p<0.05),其它参数及生物利用度均无显著差异。
A repid and sensitive reversed phase high performance liquid chromatographicprocedure for determining the concentration of Naproxen sodium in human plasmafollowing oral admintration of tables and capsules was established.The HPLCanalytical method equiped with a C18 column,UV 262 nm detector.The mobilephase consisted of 70 precent Methanol and 30 precent HAc-NaAc buffer at pH3.5.Antifan was eslected as internal standard.Naproxen sodium blood level wasmeasured in plasma collected at 10,20,40min,1,2,5,8,12,24 and 34h of dosing withtables and capsules(550 mg equal to 500 mg of Naproxen)in 8 healthy volunteers.No statiscally significant difference(p>0.1)existed between the tablet and cap-sule on bioavailability and pharmacokinetic parameters except Tm(P<0.05)
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1990年第12期531-533,共3页
Chinese Journal of Hospital Pharmacy
关键词
萘普生钠
片剂
胶囊
生物利用度
naproxen sodium tablet
naproxen sodium capsule
reversed-phase HPLC
bioavalability
pharmacokinetics
plasma drug concentration
