摘要
右美托咪啶是高度特异选择性α2肾上腺素受体激动剂,它的分布半衰期为6 min,消除半衰期为2 h,较短的分布半衰期让它成为一种理想的静脉注射药。右美托咪啶具有镇静催眠、镇痛、抑制交感神经的作用,可使麻醉药用量明显减少,抑制气管插管、拔管时的应激反应,通常作为临床麻醉的辅助药和ICU镇静药。它是一种新型的、很有前途的麻醉辅助药。
Dexmedetomidine（DEX） is a highly specific, selective and potent α2 adrenoreceptor agonist. The distribution half-life of DEX is 6 min and the elimination half-life of DEX is 2 h. The short distribution half-life of DEX makes it an ideal drug for intravenous titration. DEX has some effects of sedation, analgesia, hypnosis,inhibition of sympathetic nerve. Dexmedetomidine can significantly reduce the dose requirements for opioids and anaesthetic agents, and attenuate the stress response during tracheal intubation and tracheal extu- bation. It is a novel and promising anesthetic adjunct in the intensive care unit（ICU）.
出处
《医学综述》
2012年第10期1552-1555,共4页
Medical Recapitulate
