摘要
目的探讨骨桥蛋白在鼻咽癌组织中的表达及临床意义。方法应用免疫组织化学染色法检测44例鼻咽癌、25例癌旁正常黏膜组织骨桥蛋白的表达情况，分析骨桥蛋白的表达与鼻咽癌病理特征的关系。结果骨桥蛋白在鼻咽癌组织中的阳性表达率和阳性染色面积显著高于癌旁正常黏膜组织[77．27％（34144）比8．00％（2／25）、（60．24±17．51）％比（1．32±0．48）％]（P〈0．05）。骨桥蛋白的阳性表达与鼻咽癌的临床分期及淋巴结转移有关（JP〈0．05），而与鼻咽癌的病理分级无关（P〉0．05）。结论骨桥蛋白的表达与鼻咽癌的侵袭转移相关，骨桥蛋白过表达可能是促成鼻咽癌侵袭转移的重要因素之一。
Objective To study the expression and clinical significance of osteopontin in nasopharyngeal carcinoma tissues. Methods Osteopontin expression was determined in nasopharyngeal carcinoma tissues in 44 cases and normal mucosa tissues in 25 cases by immunohistochemical staining. The relationship between osteopontin expression and pathological features of nasopharyngeal carcinoma was analyzed. Results The positive expression rate of osteopontin in nasopharyngeal carcinoma tissues was significantly higher than that in normal tissues and the positive staining area was larger [ 77.27% （34/44） vs. 8.00% （2/25）, （60.24 ± 17.51 ）% vs. （ 1.32 ±0.48 ）% ] （P 〈 0.05 ）. The positive expression of osteopontin was correlated with clinical staging and lymph node metastasis （P 〈 0.05）,while had no relationship with pathological staging（P 〉 0.05）. Conclusions There is a close correlation between expression of osteopontin and tumor cell invasion and metastasis. Over-expression of osteopontin may be one of the important factors contributing to the invasion and migration of nasopharyngeal carcinoma.
出处
《中国医师进修杂志》
2012年第15期35-37,共3页
Chinese Journal of Postgraduates of Medicine
基金
盐城市医学科技发展计划（YK2010051）
南通大学自然科学类研究项目（102093）
关键词
鼻咽肿瘤
骨桥蛋白质
免疫组织化学
Nasopharyngeal neoplasms
Osteopontin
Immunohistochemistry
