摘要
目的 :了解肠粘液中内源性肿瘤坏死因子的水平对直结肠癌发生发展的影响。方法 :43例结肠、直肠癌患者经术中取癌灶粘液及远端正常肠粘液 ,经 EL ISA法测定其肿瘤坏死因子 (TNF- α)的水平。结果 :同一直结肠癌患者远离癌灶的正常肠粘液 TNF- α水平明显高于癌灶组 (P<0 .0 1) ,提示癌灶部分肠组织中单个核细胞分泌 TNF- α活性受到抑制 ,正常远端肠组织因肿瘤负荷导致内源性 TNF- α升高 ,而晚期患者 TNF- α活性明显低于早期患者。结论 :检测肠癌患者肠粘液 TNF- α的水平 ,可作为肠癌疗效评价及病情预后观测的指标。
Objective:To investigate the role of mucus tumor necrosis factor α in postoperative prognosis of the colorectal carcinomas Methods:In 43 patients focus mucus and distal normal intestinal mucus of colorectal carcinomas were respectively obtained from operation and their activity of TNF α were examined with ELISA method Results:Levels of TNF α in the normal intestinal mucus were markedly higher than that in the focus's(P<0 01),suggesting that activity of endogenous TNF α of monocytes in the focus was inhibited Activity of TNF a in patients with advanced colorectal carcinoma was significantly lower than those in the patients with early carcinoma Conclusion:Detection of TNF a of the intestinal mucus can be used as therapeutic evaluation and prognosis observation index for intestinal carcinoma
出处
《广西医学》
CAS
2000年第1期29-30,共2页
Guangxi Medical Journal
关键词
肿瘤坏死因子
肠粘液
结肠癌
直肠癌
预后
Tumor necrosis factor
Colorectal carcinoma
Intestinal mucus
