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DNA损伤和修复在肝癌中的研究进展 被引量：4

The research of DNA damage and repair in liver cancer
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摘要 人体细胞中DNA损伤后会引起细胞一系列反应,主要包括损伤信号的传导、损伤与修复、诱导细胞死亡等。肝癌的发生正是由于这些诱因同时作用于损伤修复系统的某个环节,使DNA损伤不能修复或不能正确修复,从而使肝细胞发生恶性转化,最后导致肝癌的发生。因此,损伤DNA的累积则成为肝癌发生的重要分子机制,对其深入研究将会为肝癌的治疗奠定基础。该文通过查阅相关文献,综述近年来DNA损伤和修复在肝癌中的研究进展。 DNA damage in human cells may cause a series of reaction, including the conduction of damaged sig- nals, DNA damage repair, induction of cell death, etc. It＇s the effect of these factors involved in damage repair sys- tem that make DNA damage which can＇t correct repair or even can＇t repair. Thus, the liver cells malignantly prolif- erate and HCC forms finally. Therefore, the accumulation of DNA damage in the HCC becomes the important molecular mechanism. And it wilt lay the foundation for the treatment of liver cancer.
作者 张阳德 王宁 廖明媚 赵劲风 杨满意 郭春芳 彭健
机构地区 中南大学肝胆肠外科研究中心
出处 《中国现代医学杂志》 CAS CSCD 北大核心 2012年第13期57-61,共5页 China Journal of Modern Medicine
基金 湖南省芙蓉学者计划课题(No:200734) 湖南省自然科学基金课题(No:10JJ5039) 中南大学中央高校基本科研业务费专项资金资助(No:2011QNZT206)
关键词 DNA损伤 DNA修复 肝癌 DNA damage DNA repair hepatocarcinoma
分类号 R735.7 [医药卫生—肿瘤]
  • 相关文献

参考文献28

  • 1LI L, SHAN Y, YANG H, et al. Upregallation of LAPTM4B-35 promotes malignant transformation and tumorigenesis in LO2 human liver cell line[J]. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology, 2011, 294(7): 1135-1142.
  • 2MCKILLOP IH, MORAN DM, JIN XL et al. Molecular pathogenesis of heptocellular carcinoma [J]. Journal of Surgical Research,2006, 136(1): 125-135.
  • 3ISHTIAQ QADRI, KANEEZ FATIMA, HANY ABDEL-HAFIZ. Hepatitis B virus X protein impedes the DNA repair via its association with transcription factor, TFIIH [J]. BMC Microbiology, 2011, 11(48): 1471-2180.
  • 4XI DAI LONG, YUN MA, YUN FENG ZHOU, et al. XPD codon 312 and 751 polymorphisms, and AFB1 exposure, and hepatocellular carcinoma risk [J]. BMC Cancer, 2009, 9(400): 1471-2407.
  • 5LIAO MM, ZHAO JF, WANG T, et al. Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells[J]. Molecular Cancer, 2011, 44(10): 44-53.
  • 6MASUTANI M, NAKAGAMA H, SUGIMURA T. Poly (ADP-ribose) and carcinogenesis [J]. Genes Chromosomes Cancer, 2003, 38: 339-348.
  • 7VIRAG L, SZABO C. The therapeutic potential of poly (ADP-ribose) polymerase inhibitors [J]. Pharmacol Rev, 2002, 54: 375-429.
  • 8OEI SL, ZIEGLER. ATP for the DNA ligation step in base excision repair is generated from polyb (ADP-ribose) [J]. J Biol Chem, 2000, 275: 23234-23239.
  • 9YANG J, YU Y, HAINRICK HE, et al. ATM, ATR and DNA-PK: initialors of the cellular genotoxic stress responses[J]. Carcinogenesis, 2003, 24: 1571-1580.
  • 10LINDAHL T, WOOD RD. Quality control by DNA repair[J]. Science, 1999, 286: 1897-1905.

二级参考文献73

  • 1潘修成,陈智,陈峰,陈晓红,周承,羊正纲.原发性肝癌组织中Kruppel样因子6基因的变异及其抗细胞增殖功能的改变[J].中华肝脏病杂志,2006,14(2):109-113. 被引量：9
  • 2PAN Xiu-cheng CHEN Zhi CHEN Feng CHEN Xiao-hong JIN Han-yin XU Xiao-yan.Inactivation of the tumor suppressor Krüppel-like factor 6 (KLF6) by mutation or decreased expression in hepatocellular carcinomas[J].Journal of Zhejiang University-Science B(Biomedicine & Biotechnology),2006,7(10):830-836. 被引量：5
  • 3邓卓霖,潘朗星,马韵,彭怀政,丁志敏.广西黄曲霉毒素高危区肝癌p53基因序列改变[J].中华肿瘤杂志,1997,19(1):18-21. 被引量：26
  • 4Mouri K,Nacher JC,Akutsu T.A mathematical model for the detection mechanism of DNA double-strand breaks depending on autophosphorylation of ATM[J].PLo S ONE,2009,4(4):e5131.
  • 5Ahmed N,Riley C,Oliva K,et al.Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritoneal tumour fluid[J].Pathol,2003,201(2):229.
  • 6Jeang KT,Xiao H,Rich EA.Multifaceted activities of the HIV-1 transactivator of transcrip tion Tat[J].Biol Chem,1999,274(41):28837.
  • 7Pardo B,Gómez-González B,Aguilera A.DNA double-strand break repair:how to fix a broken relationship[J].Cellular and Molecular Life Sciences,2009,66(6):1.
  • 8Bakkenist CJ,Kastan MB.DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation[J].Nature,2003,421(69):499.
  • 9You Z,Bailis JM,Johnson SA,et al.Rapid activation of ATM on DNA flanking double-strand breaks[J].Nat Cell Biol,2007,9(11):1311.
  • 10Cline SD,Hanawalt PC.Who′s on first in the cellular response to DNA damage[J].Nat Rev Mol Cell Biol,2003,4(5):361.

共引文献33

同被引文献51

  • 1郭桂英,石静滨,陈凤霞,徐晓颖,张卓,陈英海.吉非替尼对肝癌Bel7402细胞株放射增敏作用机制的探讨[J].中华临床医师杂志（电子版）,2012,6(19):5843-5847. 被引量：1
  • 2朱德强,黄志勇.DNA损伤与肝癌发生[J].世界华人消化杂志,2007,15(16):1775-1780. 被引量：12
  • 3何湘,钟辉.MRN复合物的结构及功能研究进展[J].生物技术通讯,2007,18(6):978-980. 被引量：7
  • 4Lee K J,Lin Y F,Chou H Y,et al.Involvement of DNA-dependent protein kinase in normal cellcycleprogression through mitosis[J].J Biol Chem,2011,286(14):12796-12802.
  • 5Hsu F M,Zhang S,Chen B P.Role of DNA-dependent protein kinasecatalytic subunit in cancerdevelopment and treatment[J].Transl Cancer Res,2012,1 (1):22-34.
  • 6Seo S B,Hur J G,Kim M J,et al.TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs/Akt/GSK-3beta pathway and activation of caspases[J].Mol Cancer,2010,28 (9):199.
  • 7Lee P C,Lee H J,Kakadiya R,et al.Multidrug-resistant cells over expressing P-glycoprotein are susceptible to DNA crosslinking agents due to attenuated Src/nuclear EGFR cascade-activated DNA repair activity[J].Oncogene,2013,32(9):1144-1154.
  • 8Bouwman P,Jonkers J.The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance[J].Nat Rev Cancer,2012,12 (9):587-598.
  • 9Curtin N J.DNA repair dysregulation from cancer driver to therapeutic target[J].Nat Rev Cancer,2012,12(12):801-817.
  • 10Rothkamm K,Krüger I,Thompson L H,et al.Pathways of DNA double-strand break repair during the mammalian cell cycle[J].Mol Cell Biol,2003,23(16):5706-5715.

引证文献4

二级引证文献12

中国现代医学杂志
2012年 第13期

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