摘要
蝙蝠葛碱(Dau)浓度依赖性抑制病人心房纤维及家兔房室结细胞APA,V_(max),减慢SR,病人心房纤维SP_4亦明显降低,并延长房室结细胞APD_(90)。利多卡因(Lid)在治疗浓度对AP各参数无明显影响,100μmol/L时明显降低病人心房纤维APA,V_(max),30μmol/L时降低兔房室结细胞V_(max)和SP_4。在两种标本,SR均呈减慢趋势。Dau明显延长家兔SACT,对SNRT,CSNRT,SNRTI和HR无明显影响,但与Lid合用可使CSNRT明显延长。提示Dau明显抑制窦房结传导功能,与Lid合用时使其自律性亦明显降低。Dau抑制心房纤维和房室结细胞AP可能为其临床上有效地治疗室上性快速型心律失常的主要电生理基础。
Dauricine(Dau),an effective antiarr-hythmic drug,produced concentration-dependent depression on the APA,Vmax and SR in human atrial fibers and rabbit atrioventricular node cells and on SP4 only in human atrial fibers,and prolonged APD90 only in rabbit atrioventricular node cells.The effects of lidocaine(Lid)on all parameters of action potential were insignificant at the treatment concentration.During the perfusion with 100μmol/L Lid,the Vmax and APA were decreased in human atrial fibers,and with 30μmol/L,Vmax and SP4 were reduced in rabbit atrioventricular node cells.In both preparations perfused with Lid,SR tended to decrease.Dau markedly increased SACT of the anesthe-tized rabbits,but had no significant effects on SNRT,CSNRT,SNRTI and HR.The action of Dau,when administered in combination with Lid,on SACT was not greater than that produced by Dau alone,but CSNRT was significantly increased.The results suggest that Dau significantly depressed the sinoatrial node conduction function,and the action potential of the atrial fibers and atrioventricular node cells,which might be related to its antagonizing effect on supraventricular arrhythmias.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1990年第4期244-247,共4页
Chinese Journal of Pharmacology and Toxicology
关键词
蝙蝠葛碱
利多卡因
窦房结
房室结
dauricine
lidocaine
sinoatrial node
atrioventricular node
action potential
