摘要
用放射免疫方法对30例慢性肺心病患者进行血清内源性洋地黄样因子浓度(SEDFC)和地高辛血药浓度(SDC)测定,结果发现:(1)慢性肺心病患者SEDFC明显低于正常,P<0.001;(2)小剂量地高辛治疗组患者平均SDC明显低于中剂量地高辛治疗组;(3)小剂量地高辛治疗组患者心律失常发生率明显低于中剂量地高辛治疗组,P<0.025;(4)SDC与SEDFC差值大于1.0μg/L患者心律失常发生率明显高于差值小于1.0μg/L患者,P<0.05;(5)发生心律失常的肺心病患者平均SDC较未发生心律失常者明显升高,P<0.05。
The determination of serum endogenous digitalis-like factor concentrations ( SEDFC ) and serum digoxin concentrations ( SDC ) was carried out in 30 patients with chronic pulmonary heart disease ( CPHD ) with radio immunoassay. The results showed that(1) the SEDFC in patients with CPHD were significantly lower than those of normal cases, P<0.001; ( 2 ) the mean SDC in patients with low-dose digoxin treatment were significantly lower than those of patients with mild-dose, P<0.05; ( 3 ) the arrhythmia rates in patients with low-dose digoxin treatment were significantly lower than those of patients with mild-dose, P<0.025; (4) the arrhythmia rates in patients whose difference between SDC and SEDFC was beyond 1.0 μg/L was significantly higher than those of patients whose difference was within 1.0 μg/L, P<0.05; (5) the mean SDC in patients with arrhythmia were significantly higher than those of patients without arrhythmia, P<0.05.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1990年第6期386-388,共3页
Chinese Pharmacological Bulletin
关键词
地高辛
血药浓度
肺心病
Endogenous digitalis-like factor
Digoxin
Serum medicine concentration
Chronic pulmonary heart disease
Arrhythmia
