摘要
目的:了解新生儿血培养病原菌分布及其常见病原菌对抗生素的耐药情况。方法:对某医院新生儿重症监护病房(NICU)的1173例患儿入院时行血培养并用MICROSCAN AUTO4进行菌株鉴定及药敏实验。结果:1173例新生儿血培养标本共检出病原菌122例,总阳性率为10.4%,其中革兰阳性菌112株,占总分离菌的91.8%,革兰阳性菌中以凝固酶阴性的葡萄球菌为主,占总分离菌的86.6%。革兰阴性菌10株,占8.2%。革兰阳性菌对抗生素耐药率最高为青霉素,依次为氨苄西林、阿莫西林/克拉维酸、亚胺培南、苯唑西林和红霉素等。革兰阴性菌对亚安培南、妥布霉素、左氧氟沙星、阿米卡星等敏感。多数产超广谱β内酰胺酶或头孢菌素酶。结论:凝固酶阴性葡萄球菌(CNS)是新生儿败血症/菌血症最常见的病原菌,对常用抗菌药物的耐药现象比较严重。应加强NICU病原菌的监测,对指导临床合理用药、防止耐药菌产生和播散有重要意义。
Objective To investigate the dirstribution and antibiotic resistance of pathogens in neonatal intensive care unit （NICU）. Methods： 1173 blood samples were cultured from NICU of chuzhou first people＇s hospital ,autoscan 4 was used for strains identification and drug sensitivity test. Result： 122 pathogenic strains were isolated from 1173 specimens and the positive rate was 10.4%. Among them, 112 strains were gram-positive bacteria（91.8%）,and the coagulase negative staphylococcus was dominant （86.6%）. 10 strains were gramegative bacteria （9.7%） .The resistance rate of gram-positive bacteria to penicillin were the highest,the next were Ampinicillin,Amoxicillin/clavulanic Acid,Imipenem,Oxacilin and Erythromycin . the most of gram-negative bacteria can produce Extented-spectrum β-lactamases （ESBLs） or AmpC. The resistance rate of to Imipenem, To- bramycin, Levofloxacin,Amikacin were rather lower. Conclusion： opportunistic bacteria like coagulase negative staphylococcus, enterobacter cloacae are the primary pathogen for neonatal septicemia/bacterimia in NICU. The situation of drug resistance is serious.The surveillance of antimicrobial resistance is very important for rational antimicrobial therapy and effective control of infections in NICU.
出处
《安徽卫生职业技术学院学报》
2012年第2期72-73,共2页
Journal of Anhui Health Vocational & Technical College
关键词
新生儿
血培养
病原菌
耐药性
Newborn
Blood culture
Pathogens
Antibiotic resistance
