摘要
目的:探讨温肾养血冲剂联合经皮穴位电刺激(transcutanclus electrical acupoint stimulation,TEAS)治疗卵巢低反应患者的临床疗效。方法:选取100例符合卵巢低反应诊断的患者按随机数字表法分为治疗组和空白对照组,每组各50例,在进入IVF-ET程序之前治疗组给予3个月经周期的温肾养血冲剂联合TEAS治疗,空白组不给予治疗,检测两组治疗前后月经第2天内分泌激素水平(包括血清黄体生成素(LH)、卵泡刺激素(FSH)、雌激素(E2))和窦卵泡数。两组患者中适宜行IVF-ET者给予拮抗剂方案促排卵治疗,观察两组获卵数、受精率、冻胚数、妊娠率。结果:(1)治疗组经3个月经周期治疗后有5例获得自然妊娠,治疗组的FSH水平治疗后比治疗前下降,有统计学差异(P<0.05);窦卵泡数增多,有统计学差异(P<0.05)。(2)治疗组Gn用量减少,获卵数及冻胚数多于空白组,有统计学差异(P<0.05)。结论:在行IVF-ET前采用温肾养血冲剂联合TEAS治疗卵巢低反应患者能够通过良性调整下丘脑-垂体-卵巢轴(HPOA)的作用,改善卵巢储备能力,使获卵数增多,从而提高妊娠率。本研究对提高卵巢低反应患者尤其是高龄不孕女性的妊娠率提供了有效的新方法。
Objectives： To explore the clinical therapeutic effect of Wenshen Yangxue Granule combined with transcutanclus electrical - aeupoint stimulation on the treatment of patients with poor ovarian response in IVF - ET. Methods： One hundred pa- tients with poor ovarian response were randomly divided into two groups, 50 for the treatment group and 50 for the control group. The patients in the treatment group were given Wenshen Yangxue Granule combined with transeutanclus electrical - acupoint stimu-lation treatment for three months before IVF - ET procedure, and the control group were not given any treatment. The changes of en- docrine hormone levels（ including FSH, LH and E2） and the number of antral follicle were observed before and after the treatment. Then the patients in the two groups underwent IVF - ET adopted GnRH - ant protocol. The manber of retrieved oocytes, the rate of fertilization and the number of frozen embryos were recorded and analyzed. Results： （ 1 ） In the treatment group, 5 patients get spontaneous pregnancy after 3 months＇ treatment. The FSH level decreased significantly （P 〈 0.05 ） and the number of antral follicle increased significantly（ P 〈 0.05）as compared with the patients in the control group. （2） The Gn dose of the treatment group was significantly lower , and the number of retrieved oocyte and frozen embryos was significantly higher（P 〈0.05）than those in the con- trol. Conclusions： The Wenshen Yangxue Granule combined with transcutanclus electrical -acupoint stimulation treatment can modulate the HPOA , enhance ovarian reserve capacity ,increase the number of retrieved oocyte ,and improve pregnance rate of the patients with poor ovarian response. This study offers a new therapeutic method for those eider infertile patients.
出处
《中国性科学》
2012年第5期32-35,共4页
Chinese Journal of Human Sexuality
基金
国家自然科学基金(81072979/H2903)
