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肠杆菌科细菌对碳青霉烯类药物耐药现状 被引量：3

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摘要 碳青霉烯类药物对超广谱β-内酰胺酶表现出的稳定性使其一直作为产酶株临床治疗的首选药物，但随着碳青霉烯类药物的大量使用，对碳青霉烯类药物耐药的肠杆菌科细菌不断出现，成为一个棘手的临床问题。耐药性的产生往往是多机制共同作用的结果，从而导致实验室检测可能存在假阳性。替加环素、多黏菌素、磷霉素等可以用于治疗碳青霉烯类耐药的菌株。应该合理、正确的使用抗菌药物减缓耐药性出现，加强医院院内感染的控制，减低耐药性传播的几率。
作者 郑瑞 王玉明 段勇
机构地区 昆明医学院第一附属医院
出处 《现代检验医学杂志》 CAS 2012年第2期7-10,14,共5页 Journal of Modern Laboratory Medicine
关键词 肠杆菌科 碳青霉烯类 耐药
分类号 R378.2 [医药卫生—病原生物学]
  • 相关文献

参考文献41

  • 1Knothe H,Shah P,Krcmery V,et al. Transferable re- sistance to cefotaxime, cefoxitin, cefamandole and ce- furoxime in clinical isolates of Klebsiella pneurnoniae and Serratia marcescens [J]. Infection. 1983,11 ( 6 ) : 315-317.
  • 2王辉,陈民钧.碳青霉烯酶:未来困扰我们的难题[J].中华内科杂志,2003,42(5):354-356. 被引量：62
  • 3Nordmann P, Cuzon G, Naas T. The real threat of K lebsiella pneumoniae carbapenemase-produci'ng bac- teria[J]. Lancet Infect Dis,2009,9(4):228-236.
  • 4Walther-Rasmussen J, Hoiby N. OXA-typeCarbapen- emases[J]. J Antimicrob Chemother, 2006, 57 (3): 373-383.
  • 5Frere JM,Galleni M, Bush K, et al. Is it necessary to change the classification of 13-1actamases[J]. J Antimi- erob Chemother, 2005,55(6) : 1051-1053.
  • 6Yang Y, P Wu, Livermore DM. Biochemical character- ization of a β-lactamase that hydrolyzes penems and carhapenems from two Serratia marcescens isolates[J]. Antimicrob Agents Chemother, 1990,34(5) : 755- 758.
  • 7Yigit H, Queenan AM, Anderson G J, et al. Novel car- bapenem-hydrolyzing β-Lactamase, KPC-1, from a earbapenem-resistant strain of Klebsiella pneumoniae [J]. Antimierob Agents Chemother, 2001, 45 (4) : 1151-1161.
  • 8汤瑾,蒋燕群,李卿,王坚镪.一例碳青霉烯类抗菌药物耐药的肺炎克雷伯菌耐药机制研究[J].检验医学,2009,24(5):343-346. 被引量：17
  • 9Miriagou V, Tzouvelekis LS, Rossiter S, et al. Imi- penem resistance in a Salmonella clinical strain due to plasmid-mediated class A carbapenemase KPC-2[J].Antimicrob Agents Chemother, 2003, 47 (4) : 1297- 1300.
  • 10Smith Moland E, Hanson ND, Herrera VL, et al. Plasmid-mediated, carbapenem-hydrolysing β-lacta-mase,KPC-2,in Kle6siella pneumoniae[J]. J Anti- microb Chemother, 2003, 51 (3) : 711-714.

二级参考文献75

  • 1季淑娟,顾怡明,谭文涛,王丹丹,冯羡菊,周志慧,俞云松,陈亚岗,李兰娟.中国部分地区大肠埃希菌和肺炎克雷伯菌超广谱β内酰胺酶基因型研究[J].中华检验医学杂志,2004,27(9):590-593. 被引量：172
  • 2Yigit H, Queenan AM, Anderson GJ, et al. Novel carbapenem- hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother, 2001,45:1151-1161.
  • 3Smith Moland E, Hanson ND, Herrera VL, et al. Plasmid- mediated, carbapenem-hydrolysing β-lactamase, KPC-2, in Klebsiella pneumoniae isolates. J Antimicrob Chemother, 2003, 51 : 711-714.
  • 4Miriagou V, Tzouvelekis LS, Rossiter S, et al. Imipenem resistance in a Salmonella clinical strain due to plasmid-mediated class A carbapenemase KPC-2. Antimicrob Agents Chernother, 2003, 47 : 1297-1300.
  • 5Yigit H, Queenan AM, Rasheed JK, et al. Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2. Antimicrob Agents Chemother, 2003,47 : 3881-3889.
  • 6Hossain A, Ferraro MJ, Pino RM, et al. Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 in an Enterobacter sp. Antimicrob Agents Chemother, 2004, 48: 4438-4440.
  • 7Woodford N, Tiemo PM Jr, Young K, et al. Outbreak of Klebsiella pneumoniae producing a new carbapenem-hydrolyzing class A beta-lactamase, KPC-3, in a New York Medical Center. Antimicrob Agents Chemother, 2004, 48: 4793-4799.
  • 8Bratu S, Landman D, Alam M, et al. Detection of KPC carbapenem-hydrolyzing enzymes in Enterobacter spp. from Brooklyn, New York. Antimicrob Agents Chemother, 2005, 49: 776-778.
  • 9Naas T, Nordmann P, Vedel G, et al. Plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC in a KlebsieUa pneumoniae isolate from France. Antimicrob Agents Chemother, 2005, 49 : 4423-4424.
  • 10Villegas MV, Lolans K, Correa A, et al. First detection of the plasmid-mediated class A carbapenemase KPC-2 in clinical isolates of Klebsiella pneumoniae from South America. Antimicrob Agents Chemother, 2006, 50: 2880-2882.

共引文献448

同被引文献27

  • 1李静,胡志东.耐碳青霉烯类抗生素肺炎克雷伯菌imp-1型金属β-内酰胺酶的检测[J].中华临床感染病杂志,2011,4(3). 被引量：2
  • 2汪复.如何应对“超级细菌”的挑战[J].中国感染与化疗杂志,2010,10(6):401-402. 被引量：7
  • 3Poirel L,Lienhard R,Potron A,et al.Plasmid-mediated carbapenem-hydrolysing beta-lactamase KPC-2in a Klebsiella pneumoniae isolate from Switzerland[J].J Antimicrob Chemother,2011,66(3):675-676.
  • 4Pasteran F,Mendez T,Rapoport M,et al.Controlling falsepositive results obtained with the Hodge and Masuda assays for detection of class a carbapenemase in species of enterobacteriaceae by incorporating boronic acid[J].J Clin Microbiol,2010,48(4):1323-1332.
  • 5Pluquet E,Arlet G,Bingen E,et al.Sensitive and specific phenotypic assay for metallo-beta-lactamase detectionin enterobacteria by use of a moxalactam disk supplemented with EDTA[J].J Clin Microbiol,2011,49(7):2667-2670.
  • 6Poirel L,Walsh TR,Cuvillier V,et al.Multiplex PCR for detection of acquired carbapenemase genes[J].Diagn Microbiol Infect Dis,2011,70(1):119-123.
  • 7Amit S,Mishali H,Kotlovsky T,et al.Bloodstream infectionsamong carriers of carbapenem-resistant Klebsiella pneumoni-ae:etiology,incidence and predictors[J].Clin Microbiol In-fect,2015,21(1):30-34.
  • 8Clancy CJ,Chen L,Shields RK,et al.Epidemiology and molec-ular characterization of bacteremia due to carbapenem-resistantKlebsiella pneumoniae in transplant recipients[J].Am JTransplant,2013,13(10):2619-2633.
  • 9Joy V.Venkataraman J,Mohamed R.Mortality associatedwith carbapenem-resistant Klebsiella pneumoniae infectionsin liver transplant recipients[J].Liver Transplant,2012,18(4):468-474.
  • 10Hou XH,Song XY,Ma XB,et al.Molecular characterization ofmultidrug-resistant Klebsiella pneumoniae isolates[J].Braz JMicrobiol,2015,46(3):759-768.

引证文献3

二级引证文献7

现代检验医学杂志
2012年 第2期

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