摘要
聚氨酯因其具有优异的力学性能和良好的生物相容性广泛地应用于医疗领域.但医用聚氨酯常常会引起蛋白吸附、血小板激活、凝血、血栓和补体激活等不良生物学反应,使其应用受到限制.仿生物膜的磷脂表面被认为是和人体最亲和的表面,聚氨酯磷脂化是提高医用聚氨酯材料生物相容性的非常有效的手段之一.近年来国内外课题组在生物医用磷脂化聚氨酯的设计、制备与生物相容性等方面开展了大量的工作,取得了重要的研究进展.本文综述了磷脂改进医用聚氨酯的最新研究成果,指出含氟磷脂化聚氨酯和可降解的磷脂聚氨酯因其优异的性能,代表了该领域的发展方向并具有重要的应用前景.
Polyurethanes （PUs） have been widely used in various biomedical devices due to their excellent physical properties and relatively good biocompatibility. However, many adverse biological reactions in vivo are triggered by the virgin surfaces of PUs, such as protein adsorption, blood coagulation, complement activation, and thrombogenicity, etc., which have hindered their more widespread applications in medicine. The biomembrane-mimicking phospholipid polymers as surface modifiers to improve hemocompatibility of various biomaterials have attracted more attention because of their excellent biocompatibility with the human tissue. Thus, phospholipid PUs are believed as one of the most promising avenues to improve biocompatibility of PUs. This review focuses on the recent progress of phospholipid PUs studies on their structure design, preparation, and biocompatibility evaluation. In particularly, the applications of fluorinated phospholipid polyurethanes and biodegradable phospholipid polyurethanes for drug delivery are highlighted, which will open up a new era in the development of biomedical polyurethanes.
出处
《中国科学：化学》
CAS
CSCD
北大核心
2012年第5期661-675,共15页
SCIENTIA SINICA Chimica
关键词
磷脂
聚氨酯
生物材料
生物相容性
phospholipid, polyurethane, biomaterials, biocompatibility
