摘要
大黄蒽醌衍生物大黄酸、大黄素和芦荟大黄素对临床常见的100株厌氧菌有很强的抑菌作用。8 μg/ml能使76～91%的厌氧菌生长被抑制,其中对最常见的脆弱类杆菌,能抑制90～100%菌株的生长。与常用抗厌氧菌药物比较,大黄蒽醌衍生物对厌氧菌的MIC虽然略高于甲硝唑,但与其他抗厌氧菌药物比较,如头孢甲氧噻吩等,其MIC大致相近或优于它们。实验还表明大黄蒽醌衍生物抗厌氧菌主要是抑菌而非杀菌。其作用部位可能是干扰厌氧菌细胞壁的形成和细胞膜的通透性。
Rhein, emodin and aloe-emodin showed strongly inhibitory effects on 100 strains of anaerobic bacteria. The growth of 76-91% anaerobic bacteria was inhibited at a concentration of 8 μg/ml. The growth of 90-100% bacteroides fragilis was also inhibited at the same concentration. In comparison with common antianaerobic bacterial drugs, the activities of anthraquinone derivatives were inferior to Metronidazol but approached or were superior to other antianaerobic bacterial drugs such as Cefoxitin. The antibacterial properties of anthraquinone derivatives were bacteriostatic but not bactericide. The localization of inhibitory effects was probably on the for-mation of cell wall and permeability of cell membrane.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1990年第6期354-357,共4页
Journal of China Pharmaceutical University
关键词
大黄
蒽醌衍生物
抗厌氧菌
Rhubarb
Anthraquinone derivatives
Anacrobic bactcria
