摘要
目的 寻找治疗顽固性频繁发作膀胱痉挛的有效药物剂型及给药途径。 方法 采用0 .75 %羧甲基纤维素钠为基质 ,加入维拉帕米、维生素K3 、阿托品制成解痉胶浆剂 ,膀胱灌注治疗膀胱痉挛频繁发作病人 10 1例次。另设硬膜外麻醉治疗此症 38例次作对照 ,观察两组显效例数 ,起效时间 ,维持时间。 结果 解痉胶浆组 10 1例次中显效 97例 (96 .5 % ) ,硬膜外麻醉组 38例次全部显效 ,起效时间两组差别无显著性意义 (P >0 .5 ) ,但维持时间解痉胶浆组长于硬膜外麻醉组 ,差别有显著性意义 (P <0 .0 1)。毒副作用 ,解痉胶浆组少于硬膜外麻醉组。 结论 解痉胶浆为治疗顽固性频繁发作膀胱痉挛的有效药物剂型 ,膀胱灌注解痉胶浆为较好的给药途径。
Objective To evaluate the efficacy of a spasmolitic mixture in the management of serious vesical spasm. Methods A mixture containing atropine,vitamin K,verapamil and the others has been used intravesically for the management of serious vesical spasm and compared with controls managed by epidural anesthesia. Results The management has been effective in 97 of 101 in the study group and in all of the 38 epidural anesthesia group.However,the spasmolitic action has been quicker and better prolonged yet without any side reaction with the use of the intravesical spasmolitic mixture. Conclusions The intravesical instillation of the spasmolitic mixture is safe,convenient and extremely effective for the relief of serious vesical spasm.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2000年第6期358-360,共3页
Chinese Journal of Urology
基金
辽宁省教育委员会资助!(960 72 2 1 0 2 3)
