摘要
目的 探讨人膀胱移行细胞癌与高危型人乳头瘤病毒感染的关系。方法 采用聚合酶链式反应 (PCR法 )检测 112例膀胱移行细胞癌组织 (包括 75例石蜡包埋组织和 3 7例手术切除组织 )和 7例正常膀胱粘膜组织的HPV 16/18感染率及HPV 16/18感染与膀胱移行细胞癌病理分级及临床分期的关系。同时检测了 2 4例膀胱癌病人尿液沉淀中HPV阳性率。结果 膀胱移行细胞癌的HPV 16/18总感染率为 62 .5 0 % ( 70 /112 ) ,与正常对照相比有显著性差异 (P <0 .0 5 )。 2 4例膀胱癌病人尿液沉淀中的HPV 18检出率为 41.67% ( 10 /2 4)。但膀胱病理分级、临床分期与HPV感染无关 (P >0 .0 5 )。结论 膀胱移行细胞癌的发生与高危型人乳头瘤病毒HPV感染可能相关 ,且很可能是膀胱移行细胞癌的早期事件之一。
Objective The relationship between the transitional cell carcinoma(TCC) of human urinary bladder and infection of high risk human papillomaviruses(HPVs) was investigated.Methods PCR was used in detection of HPVs infection in 112 TCC specimens,7 normal bladder specimens and 24 urine specimens of these patients.Results The total infection rate of high risk HPVs was 62.50%(70/112) in specimens of TCC.The detection rate of HPV 18 in the urine of patients was 41.67%(10/24).There was obvious difference between TCC and normal controls in HPV 16/18 infection rate.No relationship was found between the grade or stage of TCC and the HPVs infection.Conclusion TCC of human urinary bladder is likely associated with the infection of HPV 16/18,and this infection may be one of the early events of TCC development.
出处
《实用癌症杂志》
2000年第3期229-231,共3页
The Practical Journal of Cancer
基金
国家自然科学基金! (编号 :39370 2 91 )
关键词
膀胱癌
移动细胞癌
乳头瘤病毒感染
Transitional cell carcinoma of urinary bladder
Human papillomaviruses(HPVs)
