摘要
目的评价胺碘酮联合辛伐他汀与单用胺碘酮治疗心房颤动(房颤)的疗效。方法计算机检索Co-chrane图书馆、EMBASE及万方医学数据库等1990～2011年收录的文献,对其中胺碘酮联合辛伐他汀(试验组)与单用胺碘酮(对照组)治疗房颤的随机对照试验进行Meta分析。结果共纳入12篇文献954例。经异质性检验发现各研究结果具有同质性(P=1.0,I2=0%),故选择固定效应模型合并进行两组疗效的Meta分析,求得OR=2.98,95%CI(2.21,4.02),对总体效应进行假设检验得Z=7.18,P<0.00001,提示试验组治疗房颤的效果较对照组好。漏斗图分析结果显示两组疗效Meta分析结果存在偏倚的可能性较小。Meta分析结果示两组治疗房颤不良反应发生率比较差异无统计学意义。结论胺碘酮联合辛伐他汀治疗房颤较单用胺碘酮效果好。
Objective To evaluate the effectiveness of Amiodarone combined with Simvastatin and Amiodarone in trea- ting atrial fibrillation. Methods We retrieved the literature of Cochrane Library, EMBASE and Wangfang medical Databases, etc, which were published during 1990 to 2011. A Meta-analysis was conducted on the outcomes of randomized controlled trials （RCT） of Amiodarone with simvastatin （experimental group） and Amiodarone （control group） in treating atrial fibrillation. Re- suits We included 954 cases of 12 records in the analysis. The test for heterogeneity in all studies showed that various research results were of heterogeneity （P = 1.0, 12 = 0% ） , so a fixed effect model of Meta-analysis was conducted. The total odds ratio was 2.95, 95% confidence interval （95% CI） was from 2.21 to 4.02. The test of hypothesis for overall effects： Z=7.18, P 〈 0. 00001. The results in treatment of atrial fibrillation were better in experimental group than in control group. There was little deflective possibility in Meta-analysis result of treatment effectiveness from infundibular schema in the two groups. Meta-analytic results showed no statistical significance between the adverse reaction rates in the two groups. Conclusion Amiodarone com- bined with Simvastatin may be more effective than Amiodarone in the treatment of atrial fibrillation.
出处
《临床误诊误治》
2012年第5期66-71,共6页
Clinical Misdiagnosis & Mistherapy
基金
湖北省科技厅项目(2010CHB02301)
关键词
心房颤动
胺碘酮
辛伐他汀
药物疗法
联合
META分析
Atrial fibrillation
Amiodarone
Simvastatin
Drug therapy, combination
Meta-analysis
