摘要
观察了运动训练对纯合子ａｐｏＥ缺陷鼠脂质代谢的影响，结果表明，游泳１２周（２ｈ × ６ｄ／ｗ）后，正常Ｃ５７Ｂ／６Ｊ鼠ＴＣ、ＬＤＬ和ＴＧ均显著降低，结果分别为ＴＣ（６８．０３±１１．８９ｍｇ／ｄ１，５１．４２±１２．５９ｍｇ／ｄｌ，Ｐ＜０．０５％）、ＬＤＬ（２６．０２±５．７９ｍｇ／ｄｌ，１４．８１±８．６５ｍｇ／ｄｌ，Ｐ＜０．０５）和ＴＧ（７５．５２±１２．３１ｍｇ／ｄｌ，３９．２５±３．７３ｍｆｇ／ｄｌ，Ｐ＜０．０１），ａｐｏＥ缺陷鼠ＴＣ、ＬＤＬ和ＴＧ则显著升高，结果分别为ＴＣ（４５９．６９±１４４．１６ｍｇ／ｄｌ，７６５．３２±１５０．３５ｍｇ／ｄｌ，Ｐ＜０．０１、ＬＤＬ（３５０．６０±１０２．１５ｍｇ／ｄｌ，６８８．８５±１４７ｍｇ／ｄｌ，Ｐ＜０．０１）和ＴＧ（７２．１８±１７．４５ｍｇ／ｄｌ，１３０．６４±２５．９５ｍｇ／ｄｌ，Ｐ＜０．０１）。运动训练后ａｐｏＥ缺陷鼠血浆ＴＣ、ＴＧ和ＬＤＬ水平升高，与 ａｐｏＥ缺陷鼠体内脂质经ａｐｏＥ依赖的受体途径清除障碍有关。提示当ａｐｏＥ基因缺陷时，依靠有氧训练改善血脂状况的效果不佳。
The effects of swimming training on the lipid metabolism of homozygous ape - deficient micas were examined. Plasma TC (68. 03±11 .89 mg/dl,51 .42 ± 12.59mg/dl ,p< 0.05), LDL (26.02 ±5.79 mg/dl, 14.81±8.65 mg/dip< 0.05) and TG (75 .52 ±12. 31mg/dl,39.25 ±3 .73mg/dl, P < 0.01 ) of normal C57BL/6J mice reduced significantly after swimming training for 12 weeks (2h ×6d ). But the TC (459.69 ±144. 16 mg/dl,765.32 ± 150.35 mg/dl,p< 0.01),LDL (350.60±102.15mg/dl,688.85 ± 147 .78 mg/dl,p < 0.01 ) and TC (72. 18 ± 17 .45 mg/dl, 130.64 ± 25 .95mg/dl,p < 0.01 ) of ape - deficient mice increased re- markedly. Exercise thinning increased plasma TC, TG and LDL level in ape - deficient mice, which is associated with the delay clearance of lipid via ape - dependent receptor pathway. The results suggest that it may be inefficient for ape -deficient person to improve lipid profile dependent on aerobic exercise training.
出处
《中国运动医学杂志》
CAS
CSCD
北大核心
2000年第2期135-137,共3页
Chinese Journal of Sports Medicine
基金
国家自然科学基金!No.39770813
