摘要
目的 研究大鼠实验性肝硬变晚期腹水形成与内皮素及肠源性内毒素血症的关系 ,探讨肝硬变腹水形成的机制。方法 以大鼠为实验对象 ,分为正常对照组 (n =8)、肝硬变组 (n =12 )和肝硬变伴腹水组 (n =18)。实验组采用复合因子建立肝硬变大鼠模型。各组均测定腹主动脉血中内皮素和内毒素水平 ,肝硬变组还测定了腹水量。结果 随着肝硬变形成 ,大鼠血中内皮素水平增高 ,各组含量分别为 (99 6± 16 9) μg/L,(2 46 6± 2 1 3) μg/L和 (2 73 8± 12 4) μg/L。相关分析表明 ,肝硬变组腹水量与血中ET呈正相关 (r =0 81,P <0 0 5 ) ;内毒素水平增高 ,并与内皮素的浓度呈正相关 (r =0 74,P <0 0 5 )。结论 肝硬变腹水形成与血中内皮素升高相关 ,而内皮素的升高则源于肠源性内毒素血症的形成。
Objective To investigate the relationship between endothelin(ET)and ascites of liver cirrhotic rats. Method ET and endotoxin in blood from aorta were determined in experimental liver cirrhotic rats( n =12) and ascites in rats with ascites( n =18). Results Both cirrhosis group and cirrhosis group with ascites showed increased levels of ET and endothelin ( r =0 74, P <0 05)in the cirrhosis ascites group,and a positive correlation between ET and ascites amount( r =0 81, P <0 05). Conclusion The amount of ascites of cirrhotic rats correlates with the increase of ET with gut-derived endotoxemia. [WT5”HZ]
出处
《山西医科大学学报》
CAS
2000年第2期103-104,共2页
Journal of Shanxi Medical University
关键词
肝硬变
腹水
内皮素
内毒素血症
ascites
liver cirrhosis,experimental
endotoxemia
endotoxins
rats
