摘要
目的探讨平均血小板平均体积(MPV)和血小板分布宽度(PDW)作为血小板活化特异标志物的可行性研究。方法受试者分3组,其中健康对照组100例,心肌梗死组63例,脑梗死组54例,采用Sysmex XE-2100型全自动血细胞分析仪对所有受试者静脉血MPV、PDW进行测定。同时随机抽取广州医学院第二附属医院住院患者100例,在采血后1、2、3和4h分别检测静脉血MPV和PDW。结果与健康对照组比较,心肌梗死组、脑梗死组的MPV、PDW均升高,差异有统计学意义(P<0.01)。采血后进行不同时间检测发现,随着时间的延长,MPV增加,PDW降低。结论在血栓性疾病中MPV、PDW呈增大趋势;MPV联合PDW检测可作为血栓性疾病病情监测与预后判断的重要指标。
Objective To evaluate the feasibility of mean platelet volumn（MPV） and platelet distribution width（PDW）for platelet activation.Methods Mean platelet volume（MPV）and PDW in three groups were measured by using SysmexXE-2100 hematology analyze.The first group was healthy control subjects with 100 patients,the second group was 63 patients with myocardial infarction,and the third group was 54 patients with cerebral infarction,respectively.MPV and PDW were assessed based on the effect of storage time.Results There was a significant increase of MPV and PDW in patients with myocardial infarction or cerebral infarction,compared with healthy control subjects（P0.01）.A significant increase was observed in MPV（P0.01）,but decrease in PDW over storage time（P0.01）.Conclusion MPV and PDW are specific markers of platelet activation.P DW increases obviously during platelet activation,whereas it decreases during sample platelet swelling over storage time.
出处
《检验医学与临床》
CAS
2012年第9期1034-1035,共2页
Laboratory Medicine and Clinic
