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血浆Lp-PLA2的浓度与ACS及心血管危险因素的相关性研究 被引量：1

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摘要 目的:探讨血浆脂蛋白相关磷脂酶A2(Lp-PLA2)在急性冠脉综合征(ACS)及心血管危险因素中的浓度相关性研究。方法:入选经冠脉造影证实ACS的患者73例,(包括急性心肌梗死(AMI)组35例,不稳定心绞痛(UA)组38例)与26例健康对照组,通过酶联免疫法(ELISA)检测Lp-PLA2的浓度,与年龄、性别、吸烟情况、收缩压、舒张压、BMI、TC、LDL-C、HDL-C、TG及糖尿病等危险因素的相关性分析。结果:(1)血浆Lp-PLA2浓度在ACS组(670.70±232.22)ng/mL显著高于对照组(300.85±207.62)ng/mL,有统计学意义(P≤0.01);(2)血浆Lp-PLA2的浓度与TC、LDL-C呈正相关(r=0.383,P<0.001),与Lp-PLA2水平和HDL-C有负相关(r=-0.247,P=0.03)。结论:Lp-PLA2在ACS中是一个独立危险因素,是心血管独立预测因子,可以作为预测ACS及心血管危险因素的风险及其治疗方面具有重要意义。
作者 发尔汗 邹永伟 李娟 牟春平
机构地区 佳木斯大学第一附属医院心内科
出处 《黑龙江医药科学》 2012年第2期46-47,共2页 Heilongjiang Medicine and Pharmacy
关键词 LP-PLA2 ACS
分类号 R541 [医药卫生—心血管疾病]
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参考文献7

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二级参考文献16

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黑龙江医药科学
2012年 第2期

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