摘要
日本脑炎（Japanese encephalitis,JE）在我国又称为流行性乙型脑炎（简称乙脑）,是由日本脑炎病毒（JEV）引起的急性中枢神经系统传染病,临床以高热、惊厥、意识障碍及脑膜刺激征为主,病死率可达10%,幸存者约15%有后遗症。2010年我国卫生部公布的甲乙类法定报告传染病发病数及死亡数排序中,乙脑分别位于第15位和第7位[1],严重威胁着人民生命健康。
Japanese encephalitis virus（JEV）,categorized into the family of mosquito-borne flavivirus,causes epidemic encephalitis which poses a great threat to worldwide public health.There are no specific therapies for this disease and thus,vaccination is particularly crucial.Recent studies on JEV pathogenesis and immunity have accelerated the development of a variety of JE vaccines and their application.In this review we summarize the molecular characteristics of JEV and recent advances in the JE vaccine development.
出处
《中国病毒病杂志》
CAS
2012年第3期224-227,共4页
Chinese Journal of Viral Diseases
基金
国家自然科学基金(31100123
81171557
30872216)
关键词
日本脑炎病毒
疫苗
Japanese encephalitis virus
Vaccine
