摘要
目的研究河南省育龄期妇女风疹抗体水平,为制定先天性风疹综合征预防策略提供依据。方法随机选择15～45岁育龄妇女作为调查对象,采集血清标本,用酶联免疫吸附方法检测风疹IgG抗体,计算并比较抗体阳性率和抗体浓度。结果共选择860人作为调查对象,分成6个年龄组,平均阳性率86.6%,平均抗体浓度86.7IU/ml,其中15～20岁组阳性率、平均抗体浓度(GMC)最高(89.6%、122.0IU/ml),41～45岁组阳性率、GMC最低(51.6%、79.5IU/ml),各年龄组之间GMC差异有统计学意义(F=57.41,P<0.05),抗体阳性率差异也有统计学意义(χ2=11.11,P<0.05);分地区比较显示,不同地区抗体阳性率差异无统计学意义(χ2=0.561,P>0.05),抗体GMC值差异有统计学意义(F=3.8,P<0.05)。结论河南省育龄期妇女风疹抗体总体水平较高,但阴性率也达13.4%,随着年龄增高,抗体水平和阳性率均呈现下降趋势,为防止先天性风疹综合征(CRS)的发生,建议对抗体检测阴性育龄期妇女接种风疹疫苗。
Objective To study the serological status in reproductive women for rubella virus（RV） in Henan province,China.MethodsA total of 860 women at the reproductive age between 15-45 years of age were randomly selected and their sera were collected for the detection of IgG RV antibody.ResultsThe overall anti-RV positive rate of 860 women was 86.6% with the geometric mean concentration（GMC） at 86.7IU/ml.Both positive rates and the GMC were dropping down with the increase of age with the highest at 15-20 years of age（89.6%,122.0 IU/ml） group and the lowest at 41-45 years group（51.6%,79.5 IU/ml）（P0.05 for both comparisons）.There were no significant difference of anti-RV rates among various executive regions in Henan province（χ2=0.561,P0.05） although the anti-RV GMC levels of different regions show significant differences with the highest from populations of rural areas（F=3.8,P0.05）.ConclusionsThe immunity against rubella in reproductive women of Henan province is at high levels,whereas the negative rate is still substantially high and the immunity level decreases with the increase of age.It is of great importance and necessity to screen and vaccinate the reproductive women to prevent rebella especially the congenital rebella syndrome（CRS）.
出处
《中国病毒病杂志》
CAS
2012年第3期221-223,共3页
Chinese Journal of Viral Diseases
关键词
育龄期
风疹
免疫水平
Reproductive age
Rubella
Immunity level
