摘要
细胞因子网络是炎症及免疫应答反应的重要效应因子,特别对于获得性免疫网络的构成起到了重要的作用。近年来,以细胞因子为切入点,探讨慢性感染性疾病的发病机制、诊断、预防和治疗策略成为重要的研究方向,如白细胞介素（IL）-28B在丙型肝炎（丙肝）抗病毒治疗[1]、IL-17在重度肝。
Cytokines play important roles in initiating and shaping pathologic responses in chronic viral infection.Recent studies indicate that interleukin（IL）-21,a cytokine produced mostly by activated CD4＋ T cells and natural killer cells,regulates activation,proliferation,and survival of both CD4＋ T cells and B cells,modulates the functional activity of CD8＋ T cells and NK cells and controls the differentiation of inducible Treg and counteracts their suppressive properties on effector T cells.High level of IL-21 is correlated with HBV replication repression and HBeAg sero-conversion in chronic hepatitis B.This review focuses on the critical roles of IL-21 in chronic hepatitis B virus（HBV） infection including HBV-related acute-on-chronic liver failure.
出处
《中国病毒病杂志》
CAS
2012年第3期169-172,共4页
Chinese Journal of Viral Diseases
基金
国家自然科学基金(30730082
30901271)
国家"十一五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2012ZX10002-003)
