摘要
流行性乙型脑炎（乙脑）是由乙型脑炎病毒引起的一种人类神经系统疾病,由蚊虫传播,主要在亚洲流行,对人类特别是儿童的危害极大。全球约有60%（近30亿）的人群居住在乙脑流行地区,估计每年发生乙脑病例高达17.5万例,据世界卫生组织（WHO）统计,全球每年发生有临床症状的乙脑病例约5万例,引起1万～1.5万人死亡。
A highly attenuated and immunogenic Japanese encephalitis（JE） live vaccine（SA14-14-2） has been developed in China.Since 1989 this vaccine has been widely used in China and several other Asian countries.Recently,several novel JE vaccines have been developed based on SA14-14-2 virus strain.One of them is a purified inactivated vaccine（IC51） cultivated in Vero cells.The seed virus of this vaccine is based on the SA14-14-2 virus strain with eight passages in primary dog kidney cells.This vaccine has been licensed for use in Europe,Australia and USA.The other one is a chimeric JE/YF live vaccine（JE-CV） whose seed virus JE/YF chimera was constructed by replacing the prM and E protein genes of the YFV 17D vaccine virus with SA14-14-2 virus.JE-CV has been licensed for use in Australia.In addition,a veterinary JE live vaccine using SA14-14-2 strain as seed virus has been licensed for swine in China.Moreover,a measles-JE（SA14-14-2） combined bivalent live vaccine is under development in China and Philippines.The preclinical and clinical studies have shown promising effects.
出处
《中国病毒病杂志》
CAS
2012年第3期161-168,共8页
Chinese Journal of Viral Diseases
