摘要
目的探讨celecoxib对实验大鼠COX-2病理性表达的影响。方法通过对大鼠注入不同剂量的celecoxib,研究大鼠消化道肿瘤和膀胱肿瘤的发生率。结果不同剂量的celecoxib可降低消化道肿瘤的发生率,对胃癌有预防作用;celecoxib并不能显著减少癌前期病变发生率,但可剂量依赖性的减少膀胱肿瘤发生率。结论不同剂量的Celecoxib能抑制肿瘤细胞增殖和诱导肿瘤细胞凋亡,有效降低肿瘤的发生率,但是单独使用Celecoxib不能完全阻止肿瘤的发生。
Objective To investigate the impact of celecoxib on the rational expression of COX-2 disease in rats.Methods Different doses of celecoxib are injected in rats to study the incidence of gastrointestinal tumors and bladder tumor.Results The different doses of celecoxib can reduce the incidence of gastrointestinal tumors and have a preventive effect on gastric cancer;and celecoxib can not significantly reduce pre-cancerous lesions occurred,but have a dose-dependent decrease in bladder tumor incidence.Conclusion The different doses of celecoxib can inhibit tumor cell proliferation and induce apoptosis of tumor cells,then reduce tumor incidence effectively,but the exclusive use of celecoxib can not completely prevent the occurrence of the tumor.
出处
《中国医药指南》
2012年第12期66-67,共2页
Guide of China Medicine
