摘要
目的:分析血清心肌型脂肪酸结合蛋白(H-FABP)快速检测对急性心肌梗死(AMI)早期诊断的敏感度和特异度。方法:53例胸痛患者,经确诊分为AMI组(包括发病<6h和6～12h两亚组)和非AMI组,平行检测H-FABP、肌红蛋白(MYO)、心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB),计算H-FABP等指标诊断AMI的敏感度和特异度。结果:H-FABP诊断发病<6h AMI的敏感度为85.71%,与MYO的80.95%相近,明显高于cTnI的47.62%和CK-MB的52.38%,差异有统计学意义(P<0.05);AMI发病6～12h,H-FABP诊断AMI的敏感度为100.00%,略高于MYO、cTnI和CK-MB(均为92.86%),但差异无统计学意义(P>0.05)。H-FABP等指标诊断AMI的特异度无论非AMI组还是健康对照组,各指标间差异均无统计学意义(P>0.05)。结论:H-FABP对AMI早期诊断有较高的敏感度和特异度,可作为AMI早期筛查及诊断指标。
Objective：To analysis the sensitivity and specificity of heart-type fatty acid-binding protein（H-FABP） for early diagnosis of acute myocardial infarction（AMI）.Method：Thirty-five confirmed AMI patients were observed,the serum levels of H-FABP,cardiac troponin I（cTnI）,creatine kinase MB isoenzyme（CK-MB）,myoglobin（MYO） were detected in 6h and 6-12h after onset of chest pain,and the sensitivity of the four markers was calculated.The specificity was compared with 18 uncertain AMI patients and 40 healthy subjects.Results：The early diagnostic sensitivity of H-FABP in 6h was 85.71% in AMI,which was significantly higher than that of cTnI（47.62%） and CK-MB（52.38%）（P0.05）.The diagnostic sensitivity of H-FABP,MYO,cTnI,CK-MB in 6-12h was 100.00%,92.86%,92.86%,92.86% respectively（P0.05）.There was no significant difference in the specificity among the four markers（P0.05）.Conclusion：H-FABP has more sensitivity and specificity in the early diagnosis of AMI,which can be an important myocardial marker for both early screening and early diagnosis of AMI.
出处
《微循环学杂志》
2012年第2期37-38,42,I0001,I0002,共5页
Chinese Journal of Microcirculation
关键词
心肌型脂肪酸结合蛋白
急性心肌梗死
早期诊断
胶体金
免疫层析法
Heart-type fatty acid-binding protein
Acute myocardial infarction
Early Diagnosis
Colloidal goal
Immunochromatography
