摘要
目的分析我国溃疡性结肠炎（UC）患者的临床特征，判断临床特征与血清型标记物抗核周型粒细胞胞浆抗体（pANCA）、抗小肠杯状细胞抗体（GAB）是否存在相关性。方法按照中国炎症性肠病诊断治疗规范的共识意见对117例UC患者进行诊断描述，并记录pANCA、GAB、肠外表现、手术情况，比较各亚型之间的差异。结果我国UC患者病变范围以全结肠和左半结肠（39．3％，23．9％）为主，中，重度（39．3％，38．5％）多见。有肠外表现者为7．1％。存在病变累及范围越广越严重的趋势，总体差异有统计学意义（P〈0．05）。pANCA，GAB在UC患者中的阳性率分别为50．4％，9．4％。结论pANCA、GAB阳性与性别、年龄、临床类型、病变范围、病情程度、肠外表现等无关（P〉0．05）。
Objective To analyze the features of clinical classification of Chinese patients with ulcerative colitis （UC） , and to estimate the relationships between clinical features and Perinuclear anti - neutrophil antibody （pAN-CA）, and anti-intestinal goblet cell antibody（GAB）. Methods A retrospective study of 117 UC cases clinically di-agnosed by Chinese Consensus on diagnosis and treatment criteria of inflammatory bowel disease（IBD）. The results of pANCA, GAB, extra-intestinal manifestation, lesion range, lesion degree, were recorded and compared among different subtypes. Results The pancolitis and left-side （39.3%, 23.9% ）were predominantly noticed in Chinese UC pa-tients. Moderate and severe patients （39.3%, 38.5% ） were common. About 7. 1% of patients had extraintestinal manifestation. There was statistically difference in severity between the groups with different extent of lesion （ P 〈 0.05 ）. The positive rates of pANCA, GAB in patient with UC were 50.4% and 9.4%. Conclusions There was no sta-tistically important correlation between pANCA, GAB and gender, age, clinical types, ertraintestinal manifestations, le- sion range,lesion degree（ P 〉 0.05 ）.
出处
《医学新知》
CAS
2012年第2期99-101,104,共4页
New Medicine
关键词
溃疡性结肠炎
临床特征
抗核周型粒细胞胞浆抗体
抗小肠杯状细胞抗体
Ulcerative Colitis
clinical features
Perinuclear anti - neutrophil antibody
anti - intestinal gobletcell antibody
