摘要
目的观察稳心颗粒对慢性心力衰竭(CHF)并心房颤动患者血浆脑钠肽(BNP)、心室率及心功能的影响。方法将100例心力衰竭并发心房颤动患者随机分为对照组和治疗组各50例。对照组给予常规抗心力衰竭治疗;治疗组在对照组基础上加服稳心颗粒9 g,3次/d,冲服。分别在治疗前、后检测血浆BNP水平,观察心室率变化,测量6 min步行距离,行超声心动图检测以了解治疗前后左室射血分数。结果与对照组比较,治疗组血浆BNP降低的水平更大,心室率降低更明显,6 min步行距离更长,左心室射血分数提高更明显,两组治疗前后比较差异均有统计学意义(P<0.05)。结论稳心颗粒联合常规抗CHF治疗,能降低CHF患者血浆BNP水平,降低心室率,改善心脏功能。
Objective To observe the influence of Wenxinkeli on plasma brain natriuretic peptide（BNP）,heart rate and cardiac function of patients with chronic heart failure（CHF）and atrial fibrillation.Methods 100 patients with heart failure complicated by atrial fibrillation were randomly divided into control group of 50 patients and the treatment group of 50 patients.The control group received conventional therapy;while the treatment group were given Wenxinkeli 9g,3 times/d（dissolved in water）on the basis of control group treatment.Plasma BNP levels,changes in heart rate,6-minute walk distance,echocardiography,left ventricular ejection fraction were observed/measured before and after treatment.Results A greater degree of reduction in plasma BNP,cardiac function improvement,6-minute walk distance improvement,left ventricular ejection fraction improvement in the treatment group were more significant than the control group after treatment（P〈0.05）.Conclusion Wenxinkeli joint conventional anti-CHF therapy can reduce the plasma BNP levels,lower heart rate,and improve heart function.
出处
《医学综述》
2012年第9期1435-1436,共2页
Medical Recapitulate
关键词
稳心颗粒
慢性心力衰竭
心房颤动
Wenxinkeli
Chronic heart failure
Atrial fibrillation
