摘要
糖尿病肾病是一种尿蛋白排泄率增加,通常伴有血压升高和典型的视网膜病变的疾病。这种疾病的特点首先是出现蛋白尿,继而肾小球滤过率进行性下降,最终导致终末期肾脏病。糖尿病环境对糖尿病患者肾小球的损伤甚至加重是必要的,肾素-血管紧张素-醛固酮系统是生理功能颇为复杂的内分泌系统,对糖尿病肾病的预防、发生、发展有重要作用。肾素-血管紧张素-醛固酮系统阻断剂药物的应用在阻止糖尿病肾病的进展以及延缓发展到晚期肾脏病阶段是有效的方法。
Diabetic nephropathy（diabetic kidney disease）is defined as a rise in urinary albumin excretion rate,often associated with an increase in blood pressure,and typically with concomitant retinopathy.It is characterized firstly by albuminuria and then by a progressive decline in glomerular filtration rate,eventually resulting in end-stage renal disease（ESRD）.A diabetic milieu is required for the diabetic glomerular lesion to develop,and renin-angiotensin-aldosterone system is an endocrine system with complex physiological functions,playing an important role in prevention,development and progression of diabetic nephropathy.Using drugs that block the renin-angiotensin-aldosterone system are effective strategies for preventing the development of diabetic nephropathy delaying the progression to more advanced stages of nephropathy.
出处
《医学综述》
2012年第9期1386-1388,共3页
Medical Recapitulate
