摘要
合成并制备了纤维素-三（3，5-二甲基苯基氨基甲酸酯）手性固定相，利用高效液相色谱法首次直接拆分了5种外消旋联苯类药物，考察了流动相组成，样品结构对保留和拆分的影响。
Cellulose tris-(3, 5 - dimethylphenylcdrite) was synthesized and used as a chiral stationary phase after it was adsorpted on silica gel. Five racemic biphenyl antiliepatitis drugs have been for the first time directly resolved on the stationary phase by normal-phase high performance liquid chrmatography.The effect of 2-propanol concentration in mobile phase and the smicture of the analytes on the retention and resolution were investigated.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
2000年第3期307-310,共4页
Chinese Journal of Analytical Chemistry
基金
中国科学院重点基金
关键词
高效液相色谱法
联苯双酯
保肝药物
手性拆分
High performance liquid chromatography, cellulose-tris (3, 5 - dimethylphenylcarbamate),racemic biphenyl drugs, enantiomeric separation
