摘要
利用循环伏安、紫外光谱和粘度测定等手段 ,对二氯二乙基锡 [Et2 Sn Cl2 ]与 DNA的作用机制进行了研究 .结果表明 ,Et2 Sn Cl2 主要作用于 DNA的骨架磷酸基团 ,使 DNA构象收缩 ,相对粘度增加 ,产生减色效应 ,始终未观察到增色效应 .提出了 Et2 Sn Cl2 对 DNA可能的作用机制模型 .
In this paper, the spectrophotometric, cyclic voltammetric methods and viscosity determination were used to study the interaction of the anti tumor active Et 2SnCl 2 with DNA. The results indicate that Et 2SnCl 2 mainly reacts electrostatically with the phosphate backbone of DNA, leading to an increase of the relative viscosity of DNA and the occurring of hypochromism of DNA. No hyperchromism was observed during the whole reaction process. The molecular action mechanism of Et 2SnCl 2 with DNA was proposed. [WT5HZ]
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2000年第4期513-516,共4页
Chemical Journal of Chinese Universities
基金
国家科技部 !(批准号 :96-90 1-0 6-0 3 8)
国家自然科学基金! (批准号 :3 990 0 185 )
山西省科委重点资助项目! (批准号 :9610 3 6
