摘要
目的:探讨结直肠癌中hMLH1和hMSH2蛋白的表达的临床意义。方法:对山东省沂南县人民医院2007年2月—2010年2月间符合中国人HNPCC诊断标准的15例结直肠癌患者及同时期40例散发性结直肠癌患者的结直肠癌组织标本进行hMLH1和hMSH2蛋白检测,并对其临床病理资料进行回顾性分析。结果:15例HNPCC患者发病年龄<50岁的4人。在结直肠癌发生的部位上,10发生在右半结肠,5例发生在左半结肠。病理类型上管状腺癌3例、黏液腺癌7例、混合癌5例。分化程度上高分化3例、中分化4例、低分化癌8例。HNPCC组中hMLH1/hMSH2蛋白阴性表达共9例,其中有8例癌灶位于右半结肠,7例病理为低分化。散发组中hMLH1/hMSH2蛋白阴性表达共6例。尚未发现hMLH1和hMSH2两种蛋白在同一病例中均为阴性表达者。结论:hMLH1和hMSH2的阴性表达与癌灶部位与病理分化高度相关;可作为HNPCC的临床初步筛查指标之一。
Objective： Explore the chinical significance of hMLH1 and hMSH2 protein expression in the colorectal cancer. Methods： Detect the hMLH1 and hMSH2 protein in 15 HNPCC patients＇ colorectal cancer tissues and 40 cases＇ colorectal cancer tissues who had sporradic colorec- tal cancer in February 2007 to February 2010; and reviewed the clinical and pathological data. Re. suits： In HNPCC group, 4 numbers onset age 〈50. On the tumor location ,10 occurrence in the right half colon, 5 occurrence are in the left half colon. In pathology tape, tubular adenocarcinoma is 3 cases, mucinous adenocarcinoma is 7 cases, and mixed carcinoma is 5 cases. And well-differenti- ated is 3 cases, moderately differentiated is 4 cases, poorly differentiated is 8 cases. The negative expression of hMLH1/hMSH2 in the HNPCC group is 9 cases. 8 occurrence in the right half colon, and poorly differentiated is 7 cases. The negative expression of in the sporradic colorectal cancer group is 6 cases. Conclusion： The negative expression of hMLH1 and hMSH2 protein have significant difference in the tumor position and the degree of pathological differentiation, and highly related with them; hMLH1 and hMSH2 protein can be used as a clinnical indicator in initial screening of the HNPCC.
出处
《中国现代普通外科进展》
CAS
2012年第5期370-373,共4页
Chinese Journal of Current Advances in General Surgery
关键词
结直肠肿瘤·错配修复基因·遗传性·筛查
Colorectal neoplasms .Mismatch repair gene,Hereditary nonpolyposis colorectal cancer,Screening
