摘要
目的总结5例药物致假性巴特综合征的临床特点和治疗转归，探讨发病机制。方法回顾性分析天津医科大学总医院内分泌科2008年5月至2010年12月5例药物致假性巴特综合征患者病历资料。结果患者均为中青年女性，有长期服用泻剂和利尿剂史。临床上以正常血压、低钾代谢性碱中毒、肾素－血管紧张素-醛固酮系统的激活为特点。3例患者肾穿刺病理活检均可见球旁器增生，小动脉管壁增厚。间质可见淋巴、单核细胞浸润。肾小管可见不同程度的退行性变。早期诊断，及时停用致病性药物配合补充氯化钾治疗。实验室检查在4周内恢复正常范围。结论临床合理应用利尿剂和泻剂可减少假性巴特综合征的发生。
Objective To summarize the clinical characteristics and outcomes of Pseudo-Bartter＇s syndrome and explore its pathogenesis. Methods The clinical data of 5 cases of Pseudo-Bartter＇s syndrome at our ward from May 2008 to December 2010 was analyzed retrospectively. Results All patients were female. Long-term regimen of purgative or diuretics was prescribed. The clinical features included normotension, hypokalemic alkalosis and activation of renin-angiotensin-aldosterone. The pathological results of 3 cases of kidney biopsy showed the hyperplasia of juxtaglomerular apparatus, thickness of arteriole, infiltration of lymphocytes and monocytes and degeneration of renal tubule. Upon a definitive diagnosis, purgative or diuretics was discontinued and supplement therapy of potassium chloride initiated. The results of laboratory tests reverted to normal ranges within 4 weeks. Conclusion Purgative or diuretics should be prescribed appropriately to avoid the occurrence of Pseudo-Bartter＇s syndrome.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2012年第18期1278-1280,共3页
National Medical Journal of China
关键词
利尿药
泻药
假性巴特综合征
Diuretics
Cathartics
Pseudo-Bartter＇s syndrome
