摘要
目的 :利用周围神经营养、趋化性套接周围神经缺损 ,找出一个使周围神经自行修复的最佳间隙 ,比较其再生神经超微结构特征。方法 :将 40只大鼠的双侧坐骨神经外露于 10倍显微镜下 ,实验侧部分切除坐骨神经后留有 3 .0、5 .0、7.0和 10 .0mm的间隙用预制的动脉分别套接坐骨神经两端 ,对照侧坐骨神经切断后直接吻合 ,8周后各组行透射电镜观察。结果 :3 .0、5 .0mm小间隙神经再生最好 ,7.0mm再生差 ,而 10 .
Objective :Accordingtotheeffectofneurotophicfactor ,anexperimenthasbeendesignedtoinvestigatetheo pitinallengthofgapfornervefiberregenerationinrepairingtransectednervesandthecharacteristicsofnerveregeneration .Methods :Aseriesof 40Wisterratswererandomlydividedinto 4groupswith 10ratsineach .Thesciaticnervesoftheratswere dividedonbothsides .Ontheexperimentalside ,thesciaticnerveswereresectedandleftgapsof 3 ,5 ,7and 10mmwiderespec tively ,andthen ,thesciaticnervesoftheexperimentalsidesweretubedintoprefabricatedaorta .Onthecontralateralside ,thesci aticnervesweredividedandsuturedupinepineuralfashionunderoperationmicroscopeimmediatelywith 11-0traumaticsu tureswithnogapformingascontrol.Attheendof 8weeks ,thesciaticnervesof 5ratsfromeachgroupwereexposedandex aminedwithtransmissionelectron microscope .Result :Theexperimentshowsthatseverenervesrepairedwithagapregeneration betterthanthoserepairedend to enddirectly .Conclusion :Theoptimallengthofgapfornerveregenerationis 3 5mm .
出处
《中国矫形外科杂志》
CAS
CSCD
2000年第5期461-462,共2页
Orthopedic Journal of China
关键词
间隙
周围神经再生
透射电镜
超微结构
Gap Peripheralnerveregeneration Transmissionelectron microscope
