摘要
目的:探讨二甲双胍与克罗米芬治疗多囊卵巢综合征的疗效。方法:随机选取诊断明确的多囊卵巢综合征患者44例,治疗组23例,给予二甲双胍与克罗米芬治疗,对照组21例,只给予克罗米芬治疗。结果:治疗组的排卵率83%和周期妊娠率24%与对照组(89%、17%)比较,差异无统计学意义(P>0.05),治疗组流产率4%与对照组10%比较,差异无统计学意义(P>0.05)。治疗组子宫内膜的厚度显著厚于克罗米芬组(P<0.05)。结论:二甲双胍与克罗米芬治疗多囊卵巢综合征不孕症的疗效尚有待探讨,目前对二甲双胍的适应证存在诸多分歧,但一般认为二甲双胍可作为一种辅助治疗。
Objective：To investigate the efficacy of metformin and clomiphene in the treatment of polycystic ovary syndrome.Methods：44 patients with polycystic ovary syndrome were randomly selected,the treatment group（23 cases）were given metformin and clomiphene,the control group（21 cases）were given only clomiphene.Results：The ovulation rate and pregnancy rates were 83% and 24% in treatment group,there were 89% and 17% in the control group,the difference was not statistically significant（P0.05）.The abortion rate was 4% in treatment group and 10% in control group,the difference was not statistically significant（P0.05）.The treatment group endometrial thickness was significantly thicker than the control group（P0.05）.Conclusion：Metformin and clomiphene in treatment of polycystic ovary syndrome,infertility efficacy remains to be explored,there are many differences between the current use of metformin indications,but it generally believed that metformin can be used as an adjuvant therapy.
出处
《中外医学研究》
2012年第14期24-25,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
