摘要
目的观察替勃龙(Livial)对绝经后女性骨质疏松症患者骨密度(BMD)和骨代谢指标的影响。方法对121名年龄51～62岁、自然绝经的女性进行骨密度测定,将89例骨质疏松女性患者随机分为替勃龙组(45例)和钙剂组(44例);32名绝经后骨密度正常的女性作为对照组。各组均于用药前、用药后12、24周采用酶联免疫吸附试验(ELISA)测定骨碱性磷酸酶(sBAP)、骨钙素(sOC)、Ⅰ型胶原交联C端肽(sCTx)和尿Ⅰ型胶原交联N端肽(uNTx),用双能X线吸收法(DEXA)测定腰椎正位,股骨颈,Ward's三角和大粗隆的骨密度(BMD)。结果经治疗后,替勃龙组骨密度有所提高,而钙剂组和对照组骨密度均下降;替勃龙组的sBAP、sOC升高,sCTx、uNTx/Cr明显下降,钙剂组和对照组变化不明显。结论替勃龙治疗绝经后骨质疏松症疗效显著。单纯服用钙剂不能治疗绝经后骨质疏松症,且继续骨流失。
Objective To study the effects of Livial on bone mineral density（BMD）and bone metabolic markers in Chinese postmenopausal women.Methods According to the criteria of osteoporosis,121 Chinese postmenopausal female of the aged 51~62 were randomized into 3 groups,the normal,Livial group and Leli group.The bone alkaline phosphates（sBAP）、osteocalcin（sOC）、bone cross-linked C-telopeptides of type Ⅰcollagen（sCTx） and urine bone cross-linked N-telopeptides of typeⅠcollagen（uNTx） were measured using ELISA.BMD were measured using dual energy X-ray absorptiometry before and after medication at 12 and 24 weeks.Results After treatment,the values of BMD were significantly higher in Livial groups,otherwise lower in Leli and normal control groups.At the same time,sCTx,uNTx/Cr concentrations were significantly lower and sBAP,sOC concentrations were higher,but the concentrations in Leli and normal control groups were basically same to the value of before treatment.Conclusion The effects of Livial to treat the PMO were notable.But calcium tablet can not play a role in the treatment of osteoporosis and can not prevent the loss of bone.
出处
《中华骨质疏松和骨矿盐疾病杂志》
2012年第1期20-24,共5页
Chinese Journal Of Osteoporosis And Bone Mineral Research
基金
国家自然科学基金资助(81072943)
关键词
替勃龙
骨密度
骨质疏松
绝经后
Livial
bone mineral density
osteoporosis
postmenopausal
