摘要
背景:聚甲基丙烯酸甲酯骨水泥是其最常用的一种填充材料,但由于其存在聚合时放热、单体毒性等缺点,所以目前出现了以Cortoss为代表的生物新型骨水泥。目的:对比两种骨水泥在体外的力学性能。方法:将聚甲基丙烯酸甲酯与新型骨水泥Cortoss按照ISO5833:2002标准分别制作成抗压及抗弯模型,将制作的模型使用生物力学机测试两种骨水泥的抗弯及抗压模量,同时在制模过程中测量骨水泥聚合温度。结果与结论:与聚甲基丙烯酸甲酯骨水泥比较,Cortoss骨水泥在聚合过程中最高温度较低、抗压强度较强、抗弯模量降低,差异均有显著性意义(P<0.05),而抗弯强度间差异无显著性意义(P>0.05)。说明Cortoss生物力学强度优于聚甲基丙烯酸甲酯骨水泥,由于Cortoss在聚合时放热较少,所以其用于手术时有较好的安全性。
BACKGROUND： Polymethylmethacrylate （PMMA） is a kind of bone cement commonly used for percutaneous kyphoplasty （PKP）. However, it has inherent drawbacks, including a high curing exotherm and the incorporation of toxic components in their formulations. Now, there are some new biological bone cements, for example, Cortoss. OBJECTIVE： To compare the in vitro biomechanical properties of PMMA bone cement and Cortoss bone cement. METHODS： Both PMMA bone cement and Cortoss bone cement were used to make the anti-compression and anti-bending models according to ISO 5833：2002. Then, the compressive load strength and bending load strength were tested using mechanical testing machine. During the modeling process, the polymerization temperature was tested in their formulations. RESULTS AND CONCLUSION： The peak exotherm and bending modulus of Cortoss were significantly lower than those of PMMA, and the compressive strength was stronger than that of PMMA （P 〈 0.05）. However, there was no significant difference in bending strength （P〈0.05 ）. The biomechanical strength of Cortoss bone cement was better than that of PMMA bone cement. Due to its lower exotherm, Cortoss bone cement was safer during the operation.
出处
《中国组织工程研究》
CAS
CSCD
2012年第16期2935-2938,共4页
Chinese Journal of Tissue Engineering Research
