摘要
背景:越来越多的研究发现,维生素D及其受体与毛发有一定关系。目的:全面阐述维生素D及其受体与毛囊干细胞、毛发生长周期、信号转导以及脱发性疾病等的关系。方法:应用计算机以"维生素D、维生素D受体、毛发、脱发、基因多态性"或"vitamin D,vitamin D receptor,hair,alopecia,gene polymorphism"为检索词检索PubMed和CNKI数据库1990/2011-11发表的关于维生素D及其受体与毛发关系的文章,同一领域选择近期发表或发表在权威杂志上的文章。结果与结论:初检得到152篇文献,根据纳入排除标准选择30篇文章进行综述。目前研究显示,维生素D及其受体在毛发中扮演重要角色,其异常可导致脱发等疾病的产生,为预防和治疗脱发性疾病提供新的可能,并有望在未来广泛应用。
BACKGROUND：Increasing evidence has demonstrated that vitamin D and its receptor correlate with hair.OBJECTIVE：To fully discuss the relationship between vitamin D,vitamin D receptor and hair follicle stem cells,hair cycle,signal transduction and alopecia.METHODS：A computer online retrieval was performed in PubMed and CNKI database to search papers addressing the relationship between vitamin D,vitamin D receptor and hair published between November 1990 and November 2011 with the key words ＂ vitamin D,vitamin D receptor,hair,alopecia,gene polymorphism＂ in Chinese or English.Papers published recently or in the authoritative journals were selected.RESULTS AND CONCLUSION：A total of 152 papers were initially retrieved.According to inclusion and exclusion criteria,30 papers were selected.The current studies have shown that vitamin D and its receptor play an important role in hair and the disorder of vitamin D would lead to alopecia.Regulation of vitamin D and its receptor may be successful in preventing and treating hair disorders and is promising in future use.
出处
《中国组织工程研究》
CAS
CSCD
2012年第14期2641-2644,共4页
Chinese Journal of Tissue Engineering Research
